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Research Grants
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Host-Parasite Cellular and Molecular Interactions in Protozoal Infections
Tropical diseases such as leishmaniasis, malaria. trypanosomiasis, toxoplasmosis and amebiasis continue to plague the world, resulting in considerable morbidity and mortality, especially in the third world countries. These diseases are caused by a group of protozoa which have, over the years, undergone evolutionary adaptation to live often intracellularly in a parasitic way of life. So well-adapted have they become that they recognize the right hosts or cells to parasitize, yet at the same time they escape recognition and destruction by the host immune system. The mechanisms of such recognition and the escape of recognition are governed largely by host-parasite surface membrane interactions ...
Justice of the Peace
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Toxoplasma Gondii Co-opts Host Immune Signaling by Secretion of a Polymorphic Tyrosine Kinase, ROP16
Toxoplasma gondii is an obligate, intracellular parasite of the Apicomplexan phylum that is able to infect nearly all warm-blooded vertebrates. This capability for survival in a variety of host niches is reflected in the diversification of Toxoplasma strains. Strains differ dramatically in their interaction with hosts, and a fruitful approach towards understanding the molecular underpinnings of disease has been to identify and characterize drivers of strain-specific differences in host response. Chapter 1 provides a general introduction to Toxoplasma gondii and its ability to modulate host immunity, with special attention given to what is known about the mechanisms behind strain-specific phe...
RNA: Catalysis, Splicing, Evolution
The conference on "RNA: Catalysis, Splicing, Evolution" brought together a unique assembly of scientific leaders in this currently very important field. Two participants of this Conference, Drs. T.R. Cech and S. Altman, were just awarded the 1989 Nobel prize in chemistry, which attests to the timeliness of this volume. The critical reviews authored by these two prominent scientists are included. For those scientists with roots in this field, who do not subscribe to GENE, this is an excellent opportunity to obtain a masterly collection of papers. All the original papers and reviews have undergone the rigorous peer review of the journal "Gene".
Cat Wars
Why our cats are a danger to species diversity and human health In 1894, a lighthouse keeper named David Lyall arrived on Stephens Island off New Zealand with a cat named Tibbles. In just over a year, the Stephens Island Wren, a rare bird endemic to the island, was rendered extinct. Mounting scientific evidence confirms what many conservationists have suspected for some time—that in the United States alone, free-ranging cats are killing birds and other animals by the billions. Equally alarming are the little-known but potentially devastating public health consequences of rabies and parasitic Toxoplasma passing from cats to humans at rising rates. Cat Wars tells the story of the threats fre...
