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The focus of Volume I of the Handbook of Human Brain Function was on basic scientific principles of brain imaging as it relates to the study of human brain function. Once the scientific bases for a particular discipline are established, follow. Such is the status of brain imaging in the study of clinical applications human brain function. It is of interest to note that the 1952 Nobel Prize for Physics was awarded to Felix Bloch and Edward Purcell, who discovered that nuclei precessing in the radiofrequency range could emit a radiofrquency signal detected by a radio receiver. Their findings initiated a series of very basic re search studies on the characteristics of nuclear magnetic resonance...