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The 21st is being recognized as the Century of the Person, particularly in Medicine and Health. Person Centered Medicine, as a concept and global programmatic movement developed in collaboration with the World Medical Association, World Health Organization, International Council of Nurses and 30 other institutions over a decade of annual Geneva Conferences, places the whole person as the center of health and as the goal and protagonist of health actions. Seeking the person at the center of medicine, has meant a medicine of the person, for the person, by the person and with the person. Articulating science and humanism, it strives for a medicine informed by evidence, experience and values and...
News of Alzheimer’s disease is constantly in the headlines. Every day we hear heart-wrenching stories of people caring for a loved one who has become a shell of their former self, of projections about rising incidence rates, and of cures that are just around the corner. However, we don't see or hear from the people who actually have the disease. In Living with Alzheimer’s, Renée L. Beard argues that the exclusively negative portrayals of Alzheimer’s are grossly inaccurate. To understand what life with memory loss is really like, Beard draws on intensive observations of nearly 100 seniors undergoing cognitive evaluation, as well as post-diagnosis interviews with individuals experiencin...
This book offers an interdisciplinary reflection on the scientific and ethical issues of the notion of proof in medicine. The book poses the following questions: why does an argument convince? How does one make a rational decision in the face of contradictory data? Why and how can we prioritize levels of evidence? What is the value of physicians' professional experience in the production of evidence? By asking these questions, this book highlights the debates surrounding the notions of robustness, relevance and statistical significance regarding different conceptions of the reliability of biomedical knowledge. It is intended for both biomedical scientists (clinicians, epidemiologists, biostatisticians, etc.) and researchers in the social sciences and humanities who are interested in the social organization of clinical trials and in decision-making in a context of uncertainty. It also provides a better understanding of social issues in specific contexts, such as gynecological care, prevention policies, significance tests, and the management of the COVID-19 pandemic.
Why our approaches to Alzheimer's and dementia are problematic and contradictory Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer's disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded in current efforts to slow down or halt Alzheimer’s disease through early detection of pre-symptomatic biological changes in healthy individuals. Based on a meticulous account of the history of Alzheimer’s disease and extensive in-depth interviews, Margaret Lock highlights the limitations and the dissent associated with biomarker detection. Lock argues that basic research must continue, but should be complemented by a public health approach to prevention that is economically feasible, more humane, and much more effective globally than one exclusively focused on an increasingly harried search for a cure.
It has become clear that reductionist models of health care are unsustainable in both economic and humanistic terms.
Alzheimer’s disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the pathogenesis of Alzheimer’s disease. Some statine-based peptidomimetics show inhibitory activities to the ß-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function o...
Es geht hier um eine holistische Sichtweise. Körper, Geist und Seele können nur zusammen gesehen werden. Als Praktischer Arzt mit einem internistischen Hintergrund wie auch als Psychiater und Psychotherapeut, der Naturheilverfahren und traditionelle chinesische Medizin einbezieht, wurde dies dem Autor immer wieder nur zu klar. Moderne psychiatrische Strömungen, die sich in den psychiatrischen Weltkonferenzen der World Psychiatric Association (WPA) immer mehr zeigen, führen klar in diese Richtung. Einerseits gibt es mehr körperliche Ursachen für psychische Probleme als gedacht, und andererseits kann man über allgemeine Gesundheitssorge für den Menschen auch viel mehr für die psychisc...
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Exploring issues related to person-centred care for people with dementia, this new edition of a bestselling book shows how to provide care services that enable people to live well. The book looks at working in a person-centred way from diagnosis to end-of-life care, referencing recent developments and applications of the VIPS model.