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Built on a decade of experience with novel molecular diagnostics, this practice-oriented guide shows how to cope with validation issues during all stages of biomarker development, from the first clinical studies to the eventual commercialization of a new diagnostic test.
Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications i...
Presents the story of Plenty Coups, the last great Chief of the Crow Nation. This title contains a philosophical and ethical inquiry into a people faced with the end of their way of life.
A stunning revision of our founding document’s evolving history that forces us to confront anew the question that animated the founders so long ago: What is our Constitution? Americans widely believe that the United States Constitution was created when it was drafted in 1787 and ratified in 1788. But in a shrewd rereading of the Founding era, Jonathan Gienapp upends this long-held assumption, recovering the unknown story of American constitutional creation in the decade after its adoption—a story with explosive implications for current debates over constitutional originalism and interpretation. When the Constitution first appeared, it was shrouded in uncertainty. Not only was its meaning...
WINNER OF THE ROYAL SOCIETY TRIVEDI SCIENCE BOOK PRIZE 2024 ONE OF THE TIMES, SUNDAY TIMES AND NEW SCIENTIST BEST SCIENCE BOOKS OF THE YEAR A HUGO AWARD WINNER FOR BEST RELATED WORK 2024 THE INTERNATIONAL BESTSELLER THE #2 MOST GIFTED BOOK IN THE SOLAR SYSTEM From the bestselling authors of Soonish, a brilliant and hilarious off-world investigation into space settlement Earth is not well. The promise of starting life anew somewhere far, far away - no climate change, no war, no Twitter - beckons, and settling the stars finally seems within our grasp. Or is it? Bestselling authors Kelly and Zach Weinersmith set out to write the essential guide to a glorious future of space settlements, but aft...
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Structures of the Earth is the first study of the emergent genre of geographical writing and the metageographies that structured its spatial thought during the "Age of Disunion" and continue to illuminate spatial complexities that have been incompatible with the imperial and nationalist ideal of a monolithic China at the center of the world.
We see the stories in the newspaper nearly every day: a drug hailed as a breakthrough treatment turns out to cause harmful side effects; controls implemented to reduce air pollution are shown to generate hazardous solid waste; bans on dangerous chemicals result in the introduction of even more risky substitutes. Could our efforts to protect our health and the environment actually be making things worse? In Risk versus Risk, John D. Graham, Jonathan Baert Wiener, and their colleagues at the Harvard Center for Risk Analysis marshal an impressive set of case studies which demonstrate that all too often our nation's campaign to reduce risks to our health and the environment is at war with itself.