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Deciphering the T Cell Response in SARS-CoV-2 Infection
COVID-19 is a recently emerged infectious disease caused by the novel coronavirus SARS-CoV-2. The immune system has a primary role in pathogen elimination and a rapid and effective response can limit disease severity. In this context, T cells play the major role in cell mediated adaptive immune response. The protective role of CD4+ and CD8+ T cells has been inferred from studies on patients who recovered from SARS and MERS and accumulating data are now showing their relevance in SARS-CoV-2 infection. Moreover, memory T cells induced by previous pathogens can shape the susceptibility to, and the clinical severity of other infections, but the complete picture has yet to be elucidated. If the virus is not rapidly eliminated, COVID-19 may progress towards a secondary inflammatory phase that is directly responsible for a worsening in clinical symptoms and immune system impairment. Besides marked lymphopenia, COVID-19 patients’ T cell compartment displays several alterations involving different subpopulations of T cells in terms of phenotype, metabolic profile and functionality.
Towards Precision Medicine for Immune-Mediated Disorders: Advances in Using Big Data and Artificial Intelligence to Understand Heterogeneity in Inflammatory Responses
Topic Editor Dr. MacLeod is employed by Janssen. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Inflammation and Cancer
This second edition volume expands on the previous edition with an update on the broad spectrum of research models, techniques, and protocols used in laboratories by basic and clinical researchers. The chapters in this book are divided into two parts. Part One discusses the latest findings on the development and characterization of representative research models for chronic immune-based diseases and inflammation-associated cancers. Part Two covers biochemical, molecular, and cellular biological techniques that are commonly used to dissect the molecular mechanisms and cellular processes that drive the pathogenesis of certain disease states. Written in the highly successful Methods in Molecula...
Immune Landscape of Kidney Pathology
Topic Editor Dr. Patrick Tang holds patents related to anticancer therapy and diabetic prevention. All other Topic Editors declare no competing interests with regards to the Research Topic.
Handbook of Research on Serious Games for Educational Applications
Games have been part of the entertainment industry for decades. Once only considered viable for personal entertainment, virtual gaming media is now being explored as a useful tool for learning and student engagement. The Handbook of Research on Serious Games for Educational Applications presents a comprehensive examination of the implementation of gaming in classroom settings and the cognitive benefits this integration presents. Highlighting theoretical, psychological, instructional design, and teaching perspectives, this book is a pivotal reference source for researchers, educators, professionals, and academics interested in the innovative opportunities of game-based learning.
The Horizon Never Forgets
James Baldwin, author and civil rights activist, stated that to be Black in America and relatively conscious is to be in a state of rage almost all of the time. In this audacious debut poetry collection, The Horizon Never Forgets, Steven Moore offers us drops of honey in the tender moments we sometimes experience, especially a mother’s love. But also, drops of fire and rage when he writes about being Black, when the world ignores the pain and refuses to address the ongoing struggle to live while bearing the weight of racism. Readers feel the rage, the burn, the fury of the Black experience, and the urgency for change—but also the uplift and hope that still reside within love's possibilities.
