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Livestock and its role in the emergence, spread, and evolution of antimicrobial resistance: Animal-to-human or animal-to-environment transmission
The occurrence of multidrug-resistant bacterial pathogens (e.g., Enterobacterales and nonfermenting Gram-negative bacilli) to critically important antimicrobials such as carbapenems and colistin, last-resort antimicrobials, is a global multifactorial problem that involves animal–food–environmental–human sectors, which requires coordinated One Health and Global Health actions. The raising of food-producing animals has been increasing worldwide due to the rapid increase in demand for livestock products driven by human population growth. Consequently, the intensive use of antimicrobials in this sector has been associated with an increase in antimicrobial resistance. In this regard, the concerns associated with animal-to-human or animal-to-environment transmission of bacteria, including zoonotic pathogens, or plasmid-mediated antimicrobial resistance genes have increased in the last decade.
Prevalence, Transmission and Control of Clinically Important Antimicrobial-Resistant Bacteria/Genes within One Health Framework
Antimicrobial resistance (AMR) has emerged as a major public health issue, attracting increased attention from governments and researchers. The spread and transmission of antimicrobial resistant bacteria/genes is not only a clinical problem, but also poses unprecedented challenges in the animal husbandry industry and is closely linked to the environment. The clinically important antimicrobial resistant bacteria and their AMR genes, such as carbapenemase-producing Gram-negative Bacilli with blaNDM, blaKPC, blaIMP, blaVIM genes, colistin-resistant Gram-negative bacteria with mcr genes, methicillin-resistant Staph...
The Pangenome
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, p...
The Mosaic of Autoimmunity
This book comprehensively sets out the common aetiopathogenetic mechanisms shared by many, apparently diverse, diseases of the immune system. Unlike most other texts it does not emphasise the differences between autoimmune diseases, but establishes their many common links including hormonal effects, dietary and immunogenetic influences, complement deficiencies and environmental factors. Special attention is given to the effects of ageing and the relationship with malignancies. The scope of the book is very broad so as to cover the integration of the many diverse components which interact to cause autoimmunity, and it contains many 1988 and 1989 references and over 100 figures and tables, offering an attractive, up-to-date guide to modern concepts. It will greatly assist immunologists wishing to enter the field of autoimmunity, and will serve as an invaluable reference work for those already working in it.
Advances in Bioinformatics and Computational Biology
This book constitutes the refereed proceedings of the 11th Brazilian Symposium on Bioinformatics, BSB 2018, held in Rio de Janeiro, Brazil, in October/November 2018. The 13 revised full papers presented were carefully reviewed and selected from 26 submissions. The papers cover all aspects of bioinformatics and computational biology.
