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Bioelectrochemistry III
This book contains aseries of review papers related to the lectures given at the Third Course on Bioelectrochemistry held at Erice in November 1988, in the framework of the International School of Biophysics. The topics covered by this course, "Charge Separation Across Biomembranes, " deal with the electrochemical aspects of some basic phenomena in biological systems, such as transport of ions, ATP synthesis, formation and maintenance of ionic and protonic gradients. In the first part of the course some preliminary lectures introduce the students to the most basic phenomena and technical aspects of membrane bioelectrochemistry. The remaining part of the course is devoted to the description o...
Progress in Medicinal Chemistry
Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, ‘validation’ of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging: * HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)* 11-beta-Hydroxysteroid dehydrogenase (new approach to glucocorticoid regulation)* Nicotinic a7 choline receptor (agonists and positive allosteric modulators). * Bradykinin receptor (new approach to pain therapy)* Histone deacetylase (new drugs for cancer)* 5-HT2c receptor modulators (various CNS indications) *Presents the latest research in the field of drug discovery *Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect
Handbook of Survival Analysis
Handbook of Survival Analysis presents modern techniques and research problems in lifetime data analysis. This area of statistics deals with time-to-event data that is complicated by censoring and the dynamic nature of events occurring in time. With chapters written by leading researchers in the field, the handbook focuses on advances in survival analysis techniques, covering classical and Bayesian approaches. It gives a complete overview of the current status of survival analysis and should inspire further research in the field. Accessible to a wide range of readers, the book provides: An introduction to various areas in survival analysis for graduate students and novices A reference to modern investigations into survival analysis for more established researchers A text or supplement for a second or advanced course in survival analysis A useful guide to statistical methods for analyzing survival data experiments for practicing statisticians
Textbook Of Occupational Medicine Practice (Fourth Edition)
'The text is generally very readable, the scientific quality of the content is above reproach, and the content is very comprehensive within the confines of the size of the actual book … In my opinion, the book meets the needs of the varied targeted audience, and I would regard it as good value for money. I would consider the book useful for occupational practitioners particularly those in training who would gain a global perspective on many of the issues of occupational medicine.'Journal of Occupational MedicineThis fourth edition continues to provide a link between occupational health and clinical practice. It covers target organ systems that can be affected by hazardous exposures in work...
Contact Dermatitis
It is an unusual event for a textbook covering such a national and international networks and the use of highly specialized field as contact dermatitis to be standardized methodology, a highly differentiated published in its fourth edition within a time period picture can now be painted; we know the major p- of 13 years. When the European and Environmental fessions at risk, as well as the influences of age and Contact Dermatitis Research Group was founded in various cofactors. This is a solid basis for preventive 1985,one of the major goals was to edit a textbook of measures. A new allergen, described in one center, high scientific standard written by renown experts can now be tested on a la...
Cell Chemistry and Physiology: Part III
The first section of this volume consists of five chapters to the nature of membrane transport systems. A chapter on secondary active glucose transport has been omitted because this topic is slated to appear in the Nephrobiology module. Chapter 6 deals with oxidase control of plasma membrane proton transport, while chapter 7 addresses the question of how cell volume is regulated. Although we chose not to have a separate chapter covering additional co-transport systems namely, Na+ -K+ -2CI-, KCI, -HCO-3, as well as CI- -HCO-3 exchange and K+ and CI- movements through channels, the role of each in cell volume regulation is emphasized in Chapter 7. Instead of devoting an entire section to the t...
European Glacial Landscapes
European Glacial Landscapes: The Holocene presents the current state of knowledge on glacial landscapes of Europe and nearby areas over the Holocene to deduce the influence of atmospheric and oceanic currents and the insolation forcing variability and volcanic activity on Holocene paleoclimates, the existence of asynchronies in the timing of occurrence of glacier expansion and shrinkage during the Holocene, time lags between the identification of oceanic and atmospheric changes and those occurring in glacial extension during the Holocene, the role of Holocene glaciers on the climate of Europe, and on sea level variability, and the delimitation of landscapes that need special protection. Stud...
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
