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At the End of the Day
Note: You may read this synopsis without fear of spoiling your enjoyment of reading the book. It is carefully written not to reveal any details of the plot. If the Princeton Graduating class of 1908 were ranked financially, Logan Dean would be last. His deceased father was a congressman and so he managed to be admitted. When the novel opens he is a tough NYC investigative reporter who distinguishes himself by trying to bring to his stories a sense of history. His newspaper, the New York World, is owned by Pulitzer who is appalled over the pro British slant all the newspapers have adopted so he sends Dean to Berlin to report the war from the German side - not necessarily favoring the Kaiser. ...
Sample Preparation in Metabolomics
Metabolomics is increasingly being used to explore the dynamic responses of living systems in biochemical research. The complexity of the metabolome is outstanding, requiring the use of complementary analytical platforms and methods for its quantitative or qualitative profiling. In alignment with the selected analytical approach and the study aim, sample collection and preparation are critical steps that must be carefully selected and optimized to generate high-quality metabolomic data. This book showcases some of the most recent developments in the field of sample preparation for metabolomics studies. Novel technologies presented include electromembrane extraction of polar metabolites from plasma samples and guidelines for the preparation of biospecimens for the analysis with high-resolution μ magic-angle spinning nuclear magnetic resonance (HR-μMAS NMR). In the following chapters, the spotlight is on sample preparation approaches that have been optimized for diverse bioanalytical applications, including the analysis of cell lines, bacteria, single spheroids, extracellular vesicles, human milk, plant natural products and forest trees.
Methodologies for Metabolomics
Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.
Nutrients in Infancy
This book is a printed edition of the Special Issue "Nutrients in Infancy" that was published in Nutrients
Nuclear Magnetic Resonance
As a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Nucleic Acids" and "NMR of Carb...
Measurement and Manipulation of Intracellular Ions
This practical book provides the detailed methodology and expert guidance required for measuring and manipulating cytosolic ion concentrations. In addition, the strengths, weaknesses, and pitfalls of various techniques are presented. It is an invaluable source for those needing an objective evaluation of current methodologies and for those contemplating setting up such procedures. - A one-source reference for measuring and manipulating intracellular ions and for comparing and evaluating current methodologies - Includes overviews of Optical probes and reagents - Fabrication and use of ion-selective microelectrodes - Use of NMR spectroscopy - Ionophores
