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Almost 30 years have gone by since the postulation that GISTs derive from mesenchymal stem elements, and only 15 years have gone by since the definitive detection of origin of GISTs. Research in the last decade was more focused upon the justification of imatinib mezylate therapy in GISTs and clarification why a secondary resistance that occurred during the kinase inhibitors therapy. The era of therapy for GISTs, targeting the primary activating mutations in the KIT proto-oncogene; is being proclaimed as bringing the message of special importance to the pathologist role in multidisciplinary team that are responsible for treating patients with locally advanced or metastatic GIST. This is the first conclusive message forthcoming from this book. On the other hand, the book provides summarised and case-based knowledge on current management of gastrointestinal and extragastrointestinal stromal tumours. We hope that this book may be considered as a worthwhile timely addition to clinical science dissemination, medical education, further basic and clinical research.
A partir de un recorrido por la historia y la realidad actual de la biblioteca escolar en España, José Antonio Camacho Espinosa plantea cuáles son las condiciones que deben cumplir éstas.
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This book constitutes the thoroughly refereed post-proceedings of the 10th International Conference on Computer Aided Systems Theory, EUROCAST 2005, held in Las Palmas de Gran Canaria, Spain in February 2005. The 83 revised full papers presented were carefully reviewed and selected for inclusion in the book. The papers are organized in topical sections on formal approaches in modelling, intelligent information systems, information applications components, cryptography and spectral analysis, computer vision, biocomputing, intelligent vehicular systems, robotic soccer, robotics and control.