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Tumor microenvironment (TME) plays an important role in immunosuppressive mechanisms that result in immune editing and treatment resistance. Elucidating the diversity of stromal and immune cell distribution, polarization, and changes in their gene expression signatures will enable a better understanding of key events to improve treatment and prognosis. With the onset of immune checkpoint inhibitors (ICIs) in clinics for patients with solid tumors and hematologic malignancies, immunotherapy has taken a new direction in cancer management, especially as combination therapies. However, limitations encountered with the use of ICIs, including toxicity and immune-related adverse events (irAE) indic...
The 2022 Inter-American Yearbook on Human Rights provides an extract of the principal jurisprudence of the Inter-American Commission on Human Rights and the Inter-American Court of Human Rights. Part One contains the Decisions on the Merits of the Commission, and Part Two the Judgments and Decisions of the Court. The Yearbook is partly published as an English-Spanish bilingual edition. Some parts are in English or Spanish only. NB: This book is part of a four volume set. Vol. 1 ISBN: 978-90-04-71518-9 Vol. 2 ISBN: 978-90-04-51187-3 Vol. 3 ISBN: 978-90-04-53773-6 Vol. 4 ISBN: 978-90-04-53775-0
The poems in Chocolate Che were written in Cuba in the fiftieth year of the revolution; in India working with dying destitutes and recovering from tuberculosis; travelling up and down the spine of the Americas and into the heart of Europe on the trail of soldiers, artists and monks. Damian Furniss works images into narratives that are both darkly humorous and strangely moving. Using forms as varied as their subjects, with characteristic verbal intensity and a probing wit, he returns to the fixations of his youth in wry but reflective maturity. Along the way, he encounters the Dalai Lama and Mother Teresa; visits the houses of Pablo Picasso and Salvador Dalí, only to find no one's at home; and collects the stubs of cigars that might once have been smoked by Che Guevara and Fidel Castro, but probably weren't.
Fruit and Vegetable Phytochemicals: Chemistry, Nutritional Value and Stability provides scientists in the areas of food technology and nutrition with accessible and up-to-date information about the chemical nature, classification and analysis of the main phytochemicals present in fruits and vegetables – polyphenols and carotenoids. Special care is taken to analyze the health benefits of these compounds, their interaction with fiber, antioxidant and other biological activities, as well as the degradation processes that occur after harvest and minimal processing.
In the first in-depth study of the interconnected relationships among public theatre, custodial institutions, and women in early modern Spain, Margaret E. Boyle explores the contradictory practices of rehabilitation enacted by women both on and off stage. Pairing historical narratives and archival records with canonical and non-canonical theatrical representations of women’s deviance and rehabilitation, Unruly Women argues that women’s performances of penitence and punishment should be considered a significant factor in early modern Spanish life. Boyle considers both real-life sites of rehabilitation for women in seventeenth-century Madrid, including a jail and a magdalen house, and women onstage, where she identifies three distinct representations of female deviance: the widow, the vixen, and the murderess. Unruly Women explores these archetypal figures in order to demonstrate the ways a variety of playwrights comment on women’s non-normative relationships to the topics of marriage, sex, and violence.
Award-winning Chilean author Marcela Serrano weaves a beautiful story about the universal connections between women. For nine Chilean women, life couldn't be more different. There is the teenage computer whiz confronting her sexual identity. A middle-aged recluse who prefers the company of her dog over that of most humans. A housekeeper. A celebrity television personality. A woman confronting the loneliness of old age. Of disparate ages and races, these women represent the variety of cultural and social groups that Chile comprises. On the surface, they seem to have nothing in common...except for their beloved therapist, who brings them together. Yet as different as they all are, each woman has a story to share. As the women tell their stories, unlikely common threads are discovered, bonds are formed, and lives are transformed. Their stories form an intricate tale of triumph, heartache, and healing that will resonate with women from all walks of life. An International DUBLIN Literary Award Nominee.
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