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Innate Immunity
Innate immunity is a new branch of immunology, confirmed by three Nobel Prize winners in 2011. It is the first line of defense against pathogens and is in a way the preliminary step of adaptive immunity which occurs later, and only present in vertebrates. This book examines the way in which innate immunity was discovered in invertebrates. As a starting point, it looks at the work of Louis Pasteur on silkworm disease and the findings of Ilya Metchnikov, discoverer of phagocytosis. It also investigates André Paillot, who in 1920 demonstrated the existence of humoral immunity in insects, unrelated to the type of immunity that was initially thought to be present in all vertebrates. Finally, Innate Immunity shows how the group directed by Jules Hoffmann found strong similarities between the innate immunity response of insects and mammals. The discovery of a receptor protein in Drosophila, which is also found in humans, was what led to Jules Hoffmann being awarded the Nobel Prize in 2011.
Woodstock Nation
"Abbie Hoffman, Yippie non-leader, notorious dope addict and up-and-coming rock group (the WHAT), is currently on trial with seven others for conspiracy to incite riot during the Democratic Convention. When he returned from the Woodstock Festival he had five days before leaving for Chicago to prepare for the trial. Woodstock Nation, which the author wrote in longhand while lying upside down, stoned, on the floor of an unused office of the publisher, is the product of those five days. Other works by Mr. Hoffman include Revolution for the Hell of It and Fuck the System, which he describes as a "tender love epic"."-- Back cover.
The Tales of Hoffmann
Mary Dibbern, Music Director of Education and Family Programs at The Dallas Opera, and adjunct faculty member at the University of North Texas has created a Performance Guide for Offenbach's opera The Tales of Hoffmann. This contribution to the Vox Musicae series presents a word-by-word translation and IPA transcription of the published versions of the French libretto, and her translations of its literary sources trace the libretto's development from E.T.A. Hoffmann's "Tales." The Guide includes an interview with French opera specialist Janine Reiss, and a Foreword by Thomas Grubb. This well-rounded volume is designed for use by singers, vocal coaches, conductors, producers and directors, as well as opera-lovers.
The Beautiful Cure
“A terrific book by a consummate storyteller and scientific expert considers the past and future of the body’s ability to fight disease and heal itself.” —Adam Rutherford, The Guardian The immune system holds the key to human health. In The Beautiful Cure, leading immunologist Daniel M. Davis describes how the scientific quest to understand how the immune system works—and how it is affected by stress, sleep, age, and our state of mind—is now unlocking a revolutionary new approach to medicine and well-being. The body’s ability to fight disease and heal itself is one of the great mysteries and marvels of nature. But in recent years, painstaking research has resulted in major adva...
Tales of Hoffmann
This selection of Hoffmann's finest short stories vividly demonstrates his intense imagination and preoccupation with the supernatural, placing him at the forefront of both surrealism and the modern horror genre. Suspense dominates tales such as Mademoiselle de Scudery, in which an apprentice goldsmith and a female novelist find themselves caught up in a series of jewel thefts and murders. In the sinister Sandman, a young man's sanity is tormented by fears about a mysterious chemist, while in The Choosing of a Bride a greedy father preys on the weaknesses of his daughter's suitors. Master of the bizarre, Hoffman creates a sinister and unsettling world combining love and madness, black humour and bewildering illusion.
Nucleic Acid Sensors and Antiviral Immunity
The discovery of Toll-like receptors (TLRs) in the late 1990s ushered in a new age of discovery for innate immunity. The importance of TLRs for immunology and biomedical research was recognized with the Nobel Prize for Medicine or Physiology in 2011. The prize was shared by three scientists: Ralph Steinman (for the discovery of dendritic cells, whi
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Glycobiology of Innate Immunology
This book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility, and intracellular sign...
