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Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations
Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the tran...
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Glaucoma Research and Clinical Advances 2016 to 2018
This first volume of the New Concepts in Glaucoma series was conceived as a platform to express new ideas and approaches to understanding and solving primary open-angle glaucoma. The authors have attempted to expand levels of knowledge, present new ideas and challenge existing theories. Although the authors have painted a broad picture, the central theme of the book is to ask the right questions and seek the answers for patients with primary open-angle glaucoma.
Current Developments in Glaucoma Surgery and MIGS
Successful interventional glaucoma remains a sought-after goal for the glaucoma clinician for many reasons. Medical costs, compliance, and adherence remain major barriers for the treatment of our patients. A truly definitive treatment for glaucoma is most likely to be largely surgical, as it is doubtful that patients will continue to use glaucoma drugs in the future for anything other than transient lowering of intraocular pressure. In the coming era, it seems probable that neuroprotection and neurorestoration will be combined with MIGS to lower pressure. The different types of MIGS are increasing in proportion to their efficacy. To date, there are no fewer than 12 choices available to glaucoma specialists. Choice of procedure depends on the underlying anatomy as well as the patient’s individual characteristics. Truthfully, the number of available surgeries depends upon their taxonomy. Most are based on the outflow system and the canal, as illustrated in this book.
Glaucoma Research and Clinical Advances
Foreword Volume 2 of our serial publication continues our desire to address glaucoma with a combination of science and speculation. As science expands, the emphasis is on data, interpretation, and dogma. We disagree; open minds open new approaches. Using methodologies that are primarily molecular and genetic, we seek to refine the causes of glaucoma as well as how it is best treated, especially incorporating thoughts and hypotheses about new methods of treatment. Glaucoma is a complex disease, and genetics proves that a variety of proteins are culpable at one level. At another level, however, there are likely final common pathways and numerous feedback loops which have defied explanations to...
The Palgrave Handbook of Ageing and Physical Activity Promotion
The ageing of our population is a key societal issue across the globe. Although people are living longer, they need to be living longer in good health to continue to enjoy quality of life and independence and to prevent rises in health and social care costs. This timely and ground-breaking volume will provide an up-to-date overview of the factors that promote physical activity in later life. Despite advances in the fields of gerontology and geriatrics, sports and exercise science, sociology, health psychology, and public health, knowledge is largely contained within disciplines as reflected in the current provision of academic texts on this subject. To truly address the present and substantial societal challenges of population ageing, a multidisciplinary and collaborative approach is required. This handbook will inform researchers, students, and practitioners on the current evidence base for what physical activities need to be promoted among older people and how they can be implemented to maximise engagement. This handbook will be an invaluable resource for researchers, practitioners, policy makers, and students across the social sciences.
Ocular Fluid Dynamics
The chapters in this contributed volume showcase current theoretical approaches in the modeling of ocular fluid dynamics in health and disease. By including chapters written by experts from a variety of fields, this volume will help foster a genuinely collaborative spirit between clinical and research scientists. It vividly illustrates the advantages of clinical and experimental methods, data-driven modeling, and physically-based modeling, while also detailing the limitations of each approach. Blood, aqueous humor, vitreous humor, tear film, and cerebrospinal fluid each have a section dedicated to their anatomy and physiology, pathological conditions, imaging techniques, and mathematical mod...
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Regulation of Coronary Blood Flow
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Textbook of Shoulder Surgery
This textbook provides the most up-to-date information on shoulder surgery along with practical approaches for patient evaluation and treatments options. The book is divided into key sections, providing coverage on Soft Tissue Disorders of the Shoulder, Arthritis of the Shoulder, The Paediatric Shoulder and other miscellaneous topics relevant to treating this area. Its strong clinical focus will help residents and medical students to manage patients in a practical way, based on the most recent scientific evidence and the most effective surgical and non-surgical techniques. Thus, it will become a valuable reference and resource for young doctors and students looking to increase their professional skills and knowledge when treating shoulder injuries and disorders in clinical practice.
