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Immunosuppression by Progesterone in Pregnancy
Immunosuppression by Progesterone in Pregnancy describes a newly discovered feto-protective mechanism resulting from the interaction of the immune and endocrine systems. As a response to antigenic stimulation by the fetus, lymphocytes of pregnant women develop non-classical progesterone receptors. Receptor binding of progesterone in the lymphocytes triggers the production of a mediator protein. Through an immunological pathway, this protein prevents abortion in murine models, and its serum concentration correlates with pregnancy outcome in humans. The regulation of these unusual receptors, as well as diagnostic and therapeutic implications of the mediator protein, are discussed. Immunologists, reproductive biologists, obstetricians, gynecologists, and other researchers studying this aspect of reproductive biology will find the book to be indispensable.
Sex Hormones and Immunity to Infection
Why sex matters Among human and nonhuman animals, the prevalence and intensity of infection typically is higher in males than females and may reflect differences in exposure as well as susceptibility to pathogens. Elevated immunity among females is a double-edged sword in which it is beneficial against infectious diseases but is detrimental in terms of increased development of autoimmune diseases. The present book critically reviews the evolutionary origin and the functional mechanisms responsible for sexual dimorphism in response to infection. It emphasizes the value of examining responses in both males and females to improve our understanding about host-pathogen interactions in both sexes. The contributors are experts in their specific disciplines which range from microbiology and immunology to genetics, pathology, and evolutionary biology. The book aims at bringing insight to the treatment and management of infectious diseases; it delineates areas where knowledge is lacking and highlights future avenues of research.
Reproductive Immunology
Reproductive Immunology is a compilation of research articles presented during the VII International Congress of Reproductive Immunology which was held in New Delhi, India on 27-30 October 1998. The articles pertain to the following six major themes: Molecular and Immunological Aspects of Sperm-Egg Interaction Embryonic-Endometrial Cross-Talk Immunobiology of Pregnancy Autoantibodies and Infertility Immunocontraception Mucosal Immunology and Reproductive Tract Infections . The first section deals with our current understanding of various steps involved in fertilization. The functional significance of sperm surface mannosidase and glutathione S-transferases to bind zona pellucida is described...
Immunology of Pregnancy 2013
Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conception) and a friend (immune cells and molecules are also necessary for successful pregnancy). Leukemia Inhibitory Factor (LIF) when absent, prevents embryo implantation in rodents. From fecundation to parturition, immunity acts as a Janus, required but potentially dangerous. However, the complexity and the diversity of immunity in pregnancy deters many from entering the field. This book will try to give a complete overview of immunity from gametes till parturition, in brief, but with complete chapters and subse...
Liver Pathology
The liver is one of the organs that receives blood mostly from the systemic circulation. The liver is an important organ in which most metabolic events develop. The detoxification of toxins is also amongst the liver functions. In some cases, liver pathologies can be easily treated, and in some cases, it can lead to the end of life. Liver tumors, bacterial and viral infections, cirrhosis, and Wilson’s disease are among the most common liver diseases. Liver cancers can be primary or secondary due to metastases from other organs. Patients with secondary liver tumors can even be diagnosed without a primary tumor diagnosis. Early diagnosis of liver diseases can increase treatment success. Physicians may encounter liver diseases throughout their professional life. Therefore, our book has been prepared for all physicians. The distinguished authors in our book wrote their chapters by combining their scientific knowledge with their experiences.
Tolerating Factor VIII: Novel Strategies to Prevent and Reverse Anti-FVIII Inhibitors
The article processing charges (APCs) for some articles in this collection were partly financed by the Henry M. Jackson Foundation for the Advancement of Military Medicine, Maryland, USA (HJF), with funds which were originally granted by Grifols S.A, Barcelona, Spain (Grifols). Neither HJF nor Grifols influenced the content of any article in this collection.
Immunology of Pregnancy
Pregnancy is a unique symbiotic union between mother and fetus which contradicts many of the general rules of immunology. The maternal immune system reacts towards the foreign tissue, but instead of triggering rejection, it tolerates, supports and regulates its development. The immunological mechanisms allowing the fetus to grow and survive are complex and may be affected by internal and external factors which may result in pregnancy disorders including infertility, abortions and preeclamptic disease. In this book leading scientists present the latest findings on the physiological mechanisms required for successful pregnancies, and the pathologies that may be caused by a disturbance of these...
