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Enzyme dysfunction, an essential catalyst for the smooth running of biochemical reactions and the maintenance of vital processes, is at the root of many pathologies that have paved the way for the development of numerous drugs. Aimed at pharmacists, biologists, biochemists, doctors, veterinarians, medicinal chemists and students from a wide range of disciplines, Enzymes and Drugs brings together, for the first time, extensive documentation highlighting the relationships between a large number of drugs and enzymes. The book also highlights new prospects for therapeutic discoveries offered by enzyme targeting. Numerous applications have been developed thanks to strategies for studying enzyme inhibition or activation, as well as the development of allosteric effectors, presented with their advantages and disadvantages. Various rare diseases, known as "orphan" diseases, have resulted from enzyme deficiency or absence. For their treatment, the introduction of substitute enzymes has led to major therapeutic advances.
The VAT Carousel Fraud has seriously undermined the financial integrity of the European Union Emissions Trading Scheme (EU ETS). This timely book is the first to give an overview of fraud in the carbon market. Written by a former broker, it presents unique material on the carbon fraud mechanics and analyses the missing trader fraud (VAT fraud) on European carbon allowances markets with a focus on financial and organised crime issues. Fraud and Carbon Markets: The Carbon Connection assesses the weaknesses of the Kyoto Protocol and environmental markets, using statistics as a forensic tool on the capital markets. It describes specific cases, the court investigations and various mechanisms. It ...
C’est l’incroyable histoire vraie du braquage de Kim Kardashian, la star de téléréalité américaine de passage à Paris pour la Fashion Week, détroussée par une équipe de voleurs seniors. La nuit du 2 au 3 octobre 2016, cinq filous venus dans son hôtel de luxe, dérobent sa bague de fiançailles et une flopée de bijoux, un butin de neuf millions d’euros, avant de repartir à vélo en gilets fluo. Les pieds-nickelés viennent de réussir le casse du XXIème siècle. Mais avec la vidéosurveillance et les traces ADN, pas facile de garder le magot. Le télescopage entre ces « artistes » has been âgés de 60 à 72 ans et la Queen mondiale des réseaux sociaux, c’est la rencon...
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