Welcome to our book review site go-pdf.online!
You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
Romain Finke 2753 To the People of New York City
Der Titel von Romain Finkes aktueller Werkgruppe '2753. To the People of New York' ist Widmung und Programm zugleich. Er benennt die Zahl jener, die am 11. September 2001 beim Anschlag auf die Türme des World Trade Centers ums Leben kamen. Für jeden dieser zu früh Gestorbenen hat der Ravensburger Künstler ein Blatt angelegt. Jedes dieser gleich großen Blätter, auf dem mit Aquarellfarben ein individuelles Bild entstanden ist, steht als Symbol für ein Menschenschicksal. Es ist nicht das erste Mal, dass der 1950 geborene Romain Finke sich mit Opfern von Gewalt auseinandersetzt. 1987 schuf er den „Dachau-Zyklus“, der sich auf die Opfer der NS-Zeit bezog. '2753. To the People of New Yo...
Donor Selection for a Second Allogeneic Stem Cell Transplantation in AML Patients Relapsing After a First Transplant: a Study of the Acute Leukemia Working Party of EBMT.
Abstract: Second allogeneic stem-cell transplantation (SCT2) is a therapeutic option for patients with AML relapsing after a first transplant. Prior studies have shown similar results after SCT2 from the same or different donor; however, there are limited data on second non-T-depleted haplo-identical transplant in this setting. We retrospectively analyzed SCT2 outcomes in 556 patients, median age 46 years, relapsing after first transplant given in CR1. Patients were divided into three groups based on SCT2 donor (donor2): same donor (n = 163, sib/sib-112, UD/UD-51), different matched donor (n = 305, sib/different sib-44, sib/UD-93, UD/different UD-168), or haplo-donor (n = 88, sib/haplo-45, U...
Competing-risk Outcomes After Hematopoietic Stem Cell Transplantation from the Perspective of Time-dependent Effects
Abstract: The success of hematopoietic stem cell transplantation is determined by multiple factors. Additional complexity is conferred by covariables showing time-dependent effects. We evaluated the effect of predictors on competing-risk outcomes after hematopoietic stem cell transplantation in a time-dependent manner. We analyzed 14951 outcomes of adult patients with hematologic malignancies who underwent a first allogeneic transplant. We extended the combined endpoints of disease-free and overall survival to competing-risk settings: disease-free survival was split into relapse and non-relapse mortality. Overall survival was divided into transplant-related mortality, death from other causes and death from unknown causes. For time-dependent effects we computed estimators before and after a covariable-specific cut-point. Patients treated with reduced intensity conditioning had a constantly higher risk of relapse compared to patients treated with myeloablative conditioning. For non-relapse mortality, patients treated with reduced intensity conditioning had a reduced mortality risk but this effect was only seen in the first 4 months after transplantation (hazard ratio: 0.76, P
Age-adjusted High-dose Chemotherapy Followed by Autologous Stem Cell Transplantation Or Conventional Chemotherapy with R-MP as First-line Treatment in Elderly Primary CNS Lymphoma Patients – the Randomized Phase III PRIMA-CNS Trial
Abstract: Background Older primary central nervous system lymphoma (PCNSL) patients have an inferior prognosis compared to younger patients because available evidence on best treatment is scarce and treatment delivery is challenging due to comorbidities and reduced performance status. High-dose chemotherapy and autologous stem cell transplantation (HCT-ASCT) after high-dose methotrexate (MTX)-based immuno-chemotherapy has become an increasingly used treatment approach in eligible elderly PCNSL patients with promising feasibility and efficacy, but has not been compared with conventional chemotherapy approaches. In addition, eligibility for HCT-ASCT in elderly PCNSL is not well defined. Geriat...
Autologous Haematopoietic Stem Cell Transplantation and Other Cellular Therapy in Multiple Sclerosis and Immune-mediated Neurological Diseases: Updated Guidelines and Recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE).
Abstract: These updated EBMT guidelines review the clinical evidence, registry activity and mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple sclerosis (MS) and other immune-mediated neurological diseases and provide recommendations for patient selection, transplant technique, follow-up and future development. The major focus is on autologous HSCT (aHSCT), used in MS for over two decades and currently the fastest growing indication for this treatment in Europe, with increasing evidence to support its use in highly active relapsing remitting MS failing to respond to disease modifying therapies. aHSCT may have a potential role in the treatment of the progressi...
Association of Uric Acid Levels Before Start of Conditioning with Mortality After Allogeneic Hematopoietic Stem Cell Transplantation - a Prospective, Non-interventional Study of the EBMT Transplant Complication Working Party
Abstract: Uric acid is a danger signal contributing to inflammation. Its relevance to allogeneic stem cell transplantation (alloSCT) derives from preclinical models where the depletion of uric acid led to improved survival and reduced graft-versus-host disease (GvHD). In a clinical pilot trial, peri-transplant uric acid depletion reduced acute GvHD incidence. This prospective international multicenter study aimed to investigate the association of uric acid serum levels before start of conditioning with alloSCT outcome. We included patients with acute leukemia, lymphoma or myelodysplastic syndrome receiving a first matched sibling alloSCT from peripheral blood, regardless of conditioning. We ...
