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Current Catalog
First multi-year cumulation covers six years: 1965-70.
Targeted Therapies in Cancer:
Billions of dollars are spent every year on research into targeted therapies for cancer. That’s why it’s more than ever crucial for the thousands of scientists working in the field to keep right up to date with the cutting edge. This fascinating collection of material goes a long way to helping them do so, featuring as it does contributions to a crucial international meeting in Italy. The meeting provided a forum for scientists and clinicians working in cancer drug discovery and therapy to share their opinions and experiences. The text here offers readers an overview of diverse approaches, ranging from drug discovery to cellular therapy. Overall, the book addresses the key question of whether ultimately targeted therapy in cancer will be a myth or a reality.
Drug Discovery and Development
Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.
Small Molecules in Oncology
Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.
The Gendered Politics of Crises and De-Democratization
When opposition to gender+ equality and LGBTQIA+ policies is growing both in Europe and around the world, with increasing attacks on gender and sexuality norms and violations of women's and minority groups' rights, it is crucial to further improve the feminist scholarly understanding of opposition to gender equality in times of de-democratization. The Gendered Politics of Crises and De-Democratization: Opposition to Gender Equality seeks to broaden the current scope of literature on opposition to gender equality in democracy, laws, politics, and policymaking procedures. This book focuses on nine case studies of opposition to gender+ equality politics and policies at the United Nations' multi...
Kinase Inhibitor Drugs
A comprehensive resource on case studies of marketed kinase drugs and promising drug trials Since the discovery of protein kinase activity in 1954, the field of protein kinase drug discovery has advanced dramatically. With the ongoing clinical success of the Bcr-Abl kinase inhibitor Gleevec in the treatment of chronic myelogenous leukemia and seven additional marketed kinase inhibitor drugs, researchers have compelling evidence that kinase inhibitors can be highly efficacious in the treatment of diseases caused by aberrant activity of protein kinase. Currently more than 100 protein kinase inhibitors are in clinical development. In one comprehensive volume, the editors, Dr. Rongshi Li and Dr....
Personalized Medicine in the Making
This book offers a multidisciplinary look at the much-debated concept of “personalized medicine”. By combining a humanistic and a scientific approach, the book builds up a multidimensional way to understand the limits and potentialities of a personalized approach in medicine and healthcare. The book reflects on personalized medicine and complex diseases, the relationship between personalized medicine and the new bio-technologies, personalized medicine and personalized nutrition, and on some ethical, political, economic, and social implications of personalized medicine. This volume is of interest to researchers from several disciplines including philosophy, bio-medicine, and the social sciences. Chapter 16, “The Impact of Fantasy” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Cancer Research
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Torschrei
Kriegslast und Verdrängung, Aufbruch und Neubeginn prägen das Deutschland der Nachkriegszeit. In einem kleinbürgerlichen Elternhaus wächst ein Fußballfan heran, allein zwischen seinem autoritären Vater und seiner unglücklichen Mutter. Die Leere, die das Familienleben hinterlässt, füllt der Heranwachsende mit seiner Begeisterung für das runde Leder. Die Geschichte beginnt mit Schlammschlachten auf den Bolzplätzen der nieder-sächsischen Provinz, führt weiter über Tramptouren zu internationalen Arenen in Italien und Madrid und macht Station in West-Berlin, wo aus der Leidenschaft für den Fußball die Leidenschaft fürs Schreiben entsteht. Dazu die ersten Kneipen-Lektionen in Jour...
To a Brighter Future
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