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There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.
This book argues that the digital revolution has fundamentally altered the way musicals are produced, followed, admired, marketed, reviewed, researched, taught, and even cast. In the first hundred years of its existence, commercial musical theatre functioned on one basic model. However, with the advent of digital and network technologies, every musical theatre artist and professional has had to adjust to swift and unanticipated change. Due to the historically commercial nature of the musical theatre form, it offers a more potent test case to reveal the implications of this digital shift than other theatrical art forms. Rather than merely reflecting technological change, musical theatre scholarship and practice is at the forefront of the conversation about art in the digital age. This book is essential reading for musical theatre fans and scholars alike.
This book analyses China’s multidimensional rise in the context of the international political economy, drawing on Susan Strange’s concept of "structural power." Examining the sources of Chinese power along with its geopolitical, economic, and cultural reflections, the authors consider how China’s rise is linked with the incremental process of multipolarization in world politics. Providing a systematic, analytical, and empirically rich account of China's surge in the international political economy, this study will appeal to scholars, policy-makers, and students with interests in China studies, international political economy, and international relations.
CHOICE Award WinnerTransport and transformation processes are key for determining how humans and other organisms are exposed to chemicals. These processes are largely controlled by the chemicals' physical-chemical properties. This new edition of the Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals is a comprehen
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For the first time, a complelte record meticulously compiled of all medals awarded to the Royal Navy and Royal Marines for the Boxer Rebellion in 1900, also including the following: Legation Guard New South Wales Defence Force Victorian Naval Defence Force South Australian Defence Force Royal Indian Marine Naval Depot Wei-Hai-Wei Medals analysed and listed by bars. All no-bar medals included. Returned and duplicate medals listed in full Medals presented by HM The King noted Full and detailed Casualty Roll compiled from various sources Selected Naval Despatches are included for a fuller insight into the part played by Naval Forces in the China War of 1900.
This book presents detailed discussions of several of the large scale applications of superconductivity which will have major economic impact on technical developments in the industrial world. The world wide concern with energy problems makes this work particularly timely. Some of the large scale devices and systems such as superconducting generators, motors, power transmission, large magnets, high speed ground transportation and industrial processing clearly speak directly to improved efficiencies of generation and utilization of energy. The articles treat each subject in depth. The text is suitable for advanced undergradu ate or graduate engineering or applied science courses. The text sho...
This important work elucidates why relapse is so common for people recovering from addictive behavior problems--and what can be done to keep treatment on track. It provides an empirically supported framework for helping people with addictive behavior problems develop the skills to maintain their treatment goals, even in high-risk situations, and deal effectively with setbacks that occur. The expert contributors clearly identify the obstacles that arise in treating specific problem behaviors, review the factors that may trigger relapse at different stages of recovery, and present procedures for teaching effective cognitive and behavioral coping strategies.
Low Temperatures and Electric Power covers the proceeding of the symposium entitled ""Cryogenics in Fuel and Power Technology"" which was held in March 24-28, 1969 in London, United Kingdom. Said symposium deals with the improvement of systems for electric power and liquid natural gas delivery. The book takes on the problems of the electric power industry, large-scale refrigeration, and cryogenics, and gives different proposals for superconduction, cooling of systems, transfer of liquid natural gas, heat exchange, and energy storage. The text is recommended for electrical engineers and scientists, especially those who work for the government and aim to improve national power systems and delivery of liquid natural gas.