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Advances in Medicinal Chemistry
Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.
XIVth International Symposium on Medicinal Chemistry
Vaso-occlusive disorders including unstable angina, myocardial infarction, transient ischemic attacks, stroke and peripheral artery disease remain the major sources of morbidity and mortality in western civilization. Platelet activation and resulting platelet aggregation play a major role in the pathogenesis of these thromboembolic diseases. Recognition of the contribution of platelets to the pathophysiology of cardiovascular disease has provided impetus for the continued search for new antiplatelet agents. Hence, over the past two decades many strategies have been evaluated in the search for efficacious mechanisms to reduce platelet function. The medical need for more efficacious antithrombotic drugs and the growing understanding of the role of platelets in vascular injury have catalyzed the extensive evaluation of novel approaches to control platelet function. Along these lines, the volume therefore provides an in-depth assessment of ongoing clinical trials, new and clinically established agents, and other developments in this rapidly developing field.
Gastrointestinal Oncology
This reference discusses best practices for the management of patients with cancers of the esophagus, stomach, colon, liver, and pancreas. Focusing on a wide variety of GI carcinomas by organ and tumor type, this source provides expert coverage of diagnostic, staging, and treatment procedures by seasoned oncologists and radiologists, and offers in-
Why Forage?
4: Twenty-First-Century Hunting and Gathering among Western and Central Kalahari San / Robert K. Hitchcock and Maria Sapignoli -- 5: Why Do So Few Hadza Farm? / Nicholas Blurton Jones -- 6: In Pursuit of the Individual: Recent Economic Opportunities and the Persistence of Traditional Forager-Farmer Relationships in the Southwestern Central African Republic / Karen D. Lupo -- 7: What Now?: Big Game Hunting, Economic Change, and the Social Strategies of Bardi Men / James E. Coxworth
Cancer: How Worthwhile is Non-Curative Treatment?
Cancer is a major issue in the provision of health care. It is estimated that one in four people in developed countries are likely to develop it at some time. As longevity steadily increases, the incidence of malignant disease is expected to rise further. Important advances in the control of cancer have taken place and curative treatment has improved, notably in some of the rarer tumours, particularly in children. Advances in the more common cancers have been less marked, although adjunctive systemic treatment and population screening are lowering mortality from the most prevalent cance- carcinoma of the breast. Despite this progress, complete control of malignant disease is still a long way...
Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats
Antiviral Drug Discovery gives readers a cutting-edge view of how chemical concepts are being mobilized to develop novel approaches that will effectively confront emerging diseases and biowarfare. Among the many topics discussed are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. Each chapter discusses hypothetical strategies for the discovery of relevant antiviral agents, recent findings related to biochemistry or drug discovery, and advances in the further development of established leads in the area. Timely and informative, this book clearly delineates the efforts being made to develop new and effective broad-spectrum antiviral agents.
Fatherhood
We've all heard that a father's involvement enriches the lives of children. But how much have we heard about how having a child affects a father's life? As Peter Gray and Kermyt Anderson reveal, fatherhood actually alters a man's sexuality, rewires his brain, and changes his hormonal profile. His very health may suffer—in the short run—and improve in the long. These are just a few aspects of the scientific side of fatherhood explored in this book, which deciphers the findings of myriad studies and makes them accessible to the interested general reader. Since the mid-1990s Anderson and Gray, themselves fathers of young children, have been studying paternal behavior in places as diverse as...
The 149th Pennsylvania Volunteer Infantry Unit in the Civil War
The 149th Pennsylvania saw its one day of glory on July 1, 1863, when this young and untried regiment staged a magnificent defense at McPherson's farm. Although this bright promise quickly faded into more typical regimental experience, the story of the regiment's service under the indomitable Joshua Chamberlain remains worth telling. Drawing on the service records of more than 800 soldiers as well as diaries, letters, and other primary souces, this book details the 149th's battles from brigade to company level, from the charges at Gettsyburg to the assault at Petersburg. Focus is on the development, mood and character of a regiment as it undergoes changes in leadership, loss of reliable veterans and the increased individual desire for survival as brutal battles take their toll on mind and body. More than 100 photographs enhance the text.
