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The possibility of stimulated light emission was discussed by Einstein in 1917, eight years before the quantum-mechanical description of energy levels of many-electron systems. Though it is imperative to use samples having optical properties greatly different from the stan dard continuous spectrum of opaque objects ("black body" radia tion) it is not always necessary to restrict the study to monatomic entities. Thus, spectral lines can be obtained (in absorption and in emission) from lanthanide compounds, containing from one to thir teen 4f electrons going from trivalent cerium to ytterbium, that are nearly as sharp as the ones from gaseous atoms. However, the presence of adjacent atoms modi...
Each year public awareness of the importance of ergonomics for improving people's working conditions and home environment increases, as the application of ergonomics brings more and more tangible benefits to society at large. The Annual International Industrial Ergonomics and Safety Conference held in Copenhagen, Denmark in June 1993, sponsored by the International Foundation for Industrial Ergonomics and Safety Research brought together more than 200 ergonomic professionals from North America, Europe and Asia to present over 120 research papers, in a quest to share their knowledge of new developments in design for people and improving safety at work.; This volume is a reference on the variety of problems that industrial and office workers face today, and moreover, offers solutions in the drive towards the safe workplace.
An exploration of how the EU is influenced by multilateral institutions. There has recently been a dramatic increase in interaction between the EU and multilateral institutions. This book shows that international institutions shape EU policies, as well as acting as a source of preferences and strategies for EU stances internationally.
Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.
The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and ne...
Type 2 diabetes "mellitus" affects nearly 120 million persons worldwide- and according to the World Health Organization this number is expected to double by the year 2030. Owing to a rapidly increasing disease prevalence, the medical, social and economic burdens associated with the microvascular and macrovascular complications of type 2 diabetes are likely to increase dramatically in the coming decades. In this volume, leading contributors to the field review the pathogenesis, treatment and management of type 2 diabetes and its complications. They provide invaluable insight and share their discoveries about potentially important new techniques for the diagnosis, treatment and prevention of diabetic complications.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
1. R.C. Mehrotra, Jaipur, India Present Status and Future Potential of the Sol-Gel Process 2. J. Fricke, A. Emmerling, Wuerzburg, FRG Aerogels - Preparation, Properties, Applications 3. S. Sakka, T. Yoko, Kyoto, Japan Sol-Gel-Derived Coating Films and Applications 4. H. Schmidt, Saarbruecken, FRG Thin Films, the Chemical Processing up to Gelation 5. M. Henry, J.P. Jolivet, J. Livage, Paris, France Aqueous Chemistry of Metal Cations: Hydrolysis, Condensation and Complexation 6. R. Reisfeld, Jerusalem, Israel, C.K. Joergensen, Geneva, Switzerland Optical Properties of Colorants or Luminescent Species in Sol-Gel Glasses