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BioNMR in Drug Research
The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wüthrich. Edited by a former coworker of Wüthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids. BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D - an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies. With its successful mixture of basic information and application strategies, coupled with many real-life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers.
The American Bar
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Protein NMR for the Millennium
Protein NMR for the Millennium is the third volume in a special thematic series devoted to the latest developments in protein NMR under the Biological Magnetic Resonance umbrella. This book is divided into three major sections dealing with significant recent advances in the study of large proteins in solution and solid state, structure refinement, and screening of bioactive ligands. Key Features: TROSY, Segmental isotope labeling of proteins, Hydrogen bond scalar couplings, Structure refinement based on residual dipolar couplings, Written by the world's foremost experts who have provided broad leadership in advancing the protein NMR field.
Roots Seeds and Other Things
The Oates and related families in North Carolina and elsewhere. James Oates was in Warwick Co., Va. during the 1670's. He appeared as an attorney in the January, 1696 court in Perquimans Co., N.C. James Oates (1660-1703) married Elizabeth Eivens (d. 1705), widow of Richard Eivens, Jr. (d. 1693), 1694. She had five children from her first marriage, and one, Joseph Oates (1697-1747), from her second marriage. Joseph Oates married Elizabeth Wyatt in Albemarle Precinct, Perquimans Co., North Carolina.
Nuclear Magnetic Resonance of Biological Macromolecules, Part A
This volume and its companion, Volume 339, supplement Volumes 176, 177, 239, and 261. Chapters are written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules.
Social Work Intervention in an Economic Crisis
With the collapse of the steel industry in the 1980s, economic devastation hit the Pittsburgh, Pennsylvania, region. Social Work Intervention in an Economic Crisis strives to deepen understanding of the impact of the economic tragedy in the Pittsburgh region and to present social workers’efforts to enhance recovery. This case study serves as a model for social workers, human service educators and agency personnel, public health professionals, community organizers, policymakers, economic strategists, and researchers in social work, public health, sociology, anthropology, and political science to design and implement human service interventions for similar communities using techniques of act...
Infectious Disease Ecology
News headlines are forever reporting diseases that take huge tolls on humans, wildlife, domestic animals, and both cultivated and native plants worldwide. These diseases can also completely transform the ecosystems that feed us and provide us with other critical benefits, from flood control to water purification. And yet diseases sometimes serve to maintain the structure and function of the ecosystems on which humans depend. Gathering thirteen essays by forty leading experts who convened at the Cary Conference at the Institute of Ecosystem Studies in 2005, this book develops an integrated framework for understanding where these diseases come from, what ecological factors influence their impa...
