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Immunological Aspects of Gastroenterology
Diseases of the gastrointestinal tract are common. There is increasing appreciation of the importance of the immune system in the pathogenesis of a number of these diseases. This book covers basic aspects of innate and adaptive immunity in the gastrointestinal tract, oral tolerance, and cellular and molecular mechanisms of acute and chronic inflammation. Specific disease covered include bacterial infections, human immunodeficiency virus (HIV) infection, coeliac disease, and inflammatory bowel disease. Other topics include mucosal immunisation and intestinal transplantation immunology. The readership of this book includes clinicians, scientists, and students interested in the gastrointestinal tract.
The Liver in Biology and Disease
The Liver in Biology and Disease was conceived as a sequel in the series Principles of Medical Biology, whose general aim continues to be the integration of human biology and molecular cell biology into modern molecular medicine. It is a volume molded by the Information Revolution which few will deny has forced the teaching faculties in our medical schools to curtail and prune the teaching load and focus on fundamentals and principles. With this intention in mind, a volume of this nature takes into account the close dependence of progress in the medical sciences on bioinformatics (gene and protein analysis) or more precisely, computational biology and of course, the Internet. In general, it follows the pattern of its predecessors.*Chapters are illustrated with numerous figures and references are current*Clear, concise and accurate text about a large number of liver diseases*Describes the liver's histology, biochemistry, and pathology in molecular terms
A Practical Approach to the Spectrum of Alcoholic Liver Disease, An Issue of Clinics in Liver Disease
The Guest Editor has organized this issue to focus on the clinical management of alcoholic liver disease. Authors have written state-of-the-art reviews on the following topics: Prevalence and Natural History of ALD; Alcohol Metabolism; Immunology in ALD; Histological Findings in ALD; Diagnosis and Management of Alcoholic Hepatitis; Management of Alcohol Abuse; Long Term Management of Alcoholic Liver Disease; Infections in ALD; Nutrition in ALD; Alcohol's Effect on Other Chronic Liver Diseases; Liver Cancer and Alcohol; Evaluation and Selection of Candidates for Liver Transplantation; and ALD and Specific Transplant-Related Issues.
Bioactive Components in Milk and Dairy Products
Although bioactive compounds in milk and dairy products have been extensively studied during the last few decades – especially in human and bovine milks and some dairy products – very few publications on this topic are available, especially in other dairy species’ milk and their processed dairy products. Also, little is available in the areas of bioactive and nutraceutical compounds in bovine and human milks, while books on other mammalian species are non-existent. Bioactive Components in Milk and Dairy Products extensively covers the bioactive components in milk and dairy products of many dairy species, including cows, goats, buffalo, sheep, horse, camel, and other minor species. Park...
Amyloid and Related Disorders
The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered. Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses.
PARP Inhibitors for Cancer Therapy
PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.
The Warburg Effect Regulation Under Siege: The Intertwined Pathways in Health and Disease
Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.
Immunology of Milk and the Neonate
In the course of history, humans have attempted to interrupt the physiological and psychological bond formed between a nursing mother and her child by substituting breastfeeding with artificial formulas. A growing body of evidence indicates that breast milk, quite apart from its unsurpassed nutritive value, contains a large number of substances that protect the offspring from common infectious agents and allergens and promote the maturation of the gastrointestinal tract and the immune system. In addition to well described milk antibodies and soluble mediators of innate immunity, milk cells and pluripotent secreted factors - cytokines - are currently in the forefront of extensive research wit...
Comprehensive Handbook of Alcohol Related Pathology
This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike. *Over 100 chapters conveniently divided into 3 sections *Represents a 'one-stop-shop' of information with suitable indexing of the various pathways and processes *Each chapter is highly illustrated with tables as well as figures
