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Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development. Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucl...
Comprehensive Natural Products Chemistry
The Many Faces of RNA is the subject for the eighth SmithKline Beecham Pharmaceuticals Research Symposia. It highlights a rapidly developing area of scientific investigation. The style and format are deliberately designed to promote in-depth presentations and discussions and to facilitate the forging of collaborations between academic and industrial partners.This symposium focuses on several of the many fundamental, advancing strategies for exploring RNA and its functions. It emphasizes the interplay between biology, chemistry, genomics, and molecular biology which is leading to exciting new insights and avenues of investigation. The book explores RNA as a therapeutic target, RNA as a tool, RNA and its interactions, along with chemical, computational, and structural investigations.
This book brings together the recent advances in the area of microbial bioremediation with a particular focus on the exciting new field of multiomics technologies.
In King of the Jungle, the bouts of ethno-religious violence in Jos are fused with the heartbreaking story of two brothers who go through life unaware of each other’s existence. Carefully crafted with local colour which evokes memories of pre-2001 Jos, Bizuum Yadok’s first novel weaves humour, urban realism, tragedy and redemption.
In this edited collection, contributors analyze how the media is navigating Nigeria and its mediated democracy. Scholars of journalism, political communication, and media studies will find this book of particular interest.
Pesticides—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Acaricides. The editors have built Pesticides—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Acaricides in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Pesticides—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Climate change has emerged as one of the most severe global threats in recent years, necessitating urgent interventions. The Paris Agreement on climate change and the United Nations through the Sustainable Development Goals (SDGs) have established ingenious targets for mitigating greenhouse gas emissions, thus charting a path to a more ecologically friendly energy system. Energy accessibility is often restricted in developing economies, where conventional energy sources like coal, oil, and natural gas are still primarily utilized. However, the inimical effects of traditional energy sources such as fossil fuels on the environment and health and the quest for measures to counteract climate cha...
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering recent advances in the field of neurobiology. Topics covered include chromosome 22 deletion syndrome and schizophrenia; characterization of proteome of human cerebrospinal fluid; hormonal pathways regulating intermale and interfemale aggression; neuronal gap junctions; effects of genes and stress on the neurobiology of depression; quantitative imaging with teh MicroPET small-animal PET tomograph; understanding myelination through studying its evolution.