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Traces the founding of IWGIA (International Work Group for Indigenous People) in 1968 and its subsequent development into a professional organization concerned with human rights activities, empowerment projects, publishing and information dissemination, etc.
In the 1990s, Latin America emerged from the horror of massive human rights violations as it returned to civilian-elected regimes. This volume aims to explore the lasting legacy of the transformations brought about by the oppressive regimes of the '70s and '80s as they are experienced in the cultural, social and intellectual life of the region.
An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals.This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide basic and advanced techniques for metallomics. Speciation and imaging of metals are basic approaches to reveal the function of the metallome. The applications o...
In Smoldering Ashes Charles F. Walker interprets the end of Spanish domination in Peru and that country’s shaky transition to an autonomous republican state. Placing the indigenous population at the center of his analysis, Walker shows how the Indian peasants played a crucial and previously unacknowledged role in the battle against colonialism and in the political clashes of the early republican period. With its focus on Cuzco, the former capital of the Inca Empire, Smoldering Ashes highlights the promises and frustrations of a critical period whose long shadow remains cast on modern Peru. Peru’s Indian majority and non-Indian elite were both opposed to Spanish rule, and both groups part...
Charles Walker examines the largest rebellion in the history of Spain's American empire, led by Latin America's most iconic revolutionary, Tupac Amaru, and his wife. It began in 1780 as a multiclass alliance against European-born usurpers but degenerated into a vicious caste war, leaving a legacy that still influences South American politics today.
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The bestselling biography of the world's biggest boy band, now fully revised and updated.
This volume aims to provide protocols on a wide range of biochemical methods, analytical approaches, and bioinformatics tools developed to analyze the proteome. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Proteomics: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.