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Magnetic Resonance Brain Imaging
  • Language: en
  • Pages: 268

Magnetic Resonance Brain Imaging

This book discusses modelling and analysis of Magnetic Resonance Imaging (MRI) data of the human brain. For the data processing pipelines we rely on R, the software environment for statistical computing and graphics. The book is intended for readers from two communities: Statisticians, who are interested in neuroimaging and look for an introduction to the acquired data and typical scientific problems in the field and neuroimaging students, who want to learn about the statistical modeling and analysis of MRI data. Being a practical introduction, the book focuses on those problems in data analysis for which implementations within R are available. By providing full worked-out examples the book ...

Magnetic Resonance Brain Imaging
  • Language: en
  • Pages: 231

Magnetic Resonance Brain Imaging

This book discusses the modeling and analysis of magnetic resonance imaging (MRI) data acquired from the human brain. The data processing pipelines described rely on R. The book is intended for readers from two communities: Statisticians who are interested in neuroimaging and looking for an introduction to the acquired data and typical scientific problems in the field; and neuroimaging students wanting to learn about the statistical modeling and analysis of MRI data. Offering a practical introduction to the field, the book focuses on those problems in data analysis for which implementations within R are available. It also includes fully worked examples and as such serves as a tutorial on MRI...

Analysing FMRI Experiments with the Fmri Package in R. Version 1.0
  • Language: en

Analysing FMRI Experiments with the Fmri Package in R. Version 1.0

  • Type: Book
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  • Published: 2006
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  • Publisher: Unknown

None

Analysing FMRI Experiments with Structural Adaptive Smoothing Procedures
  • Language: en
  • Pages: 19
HMRI - A Toolbox for Using Quantitative MRI in Neuroscience and Clinical Research
  • Language: en

HMRI - A Toolbox for Using Quantitative MRI in Neuroscience and Clinical Research

  • Type: Book
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  • Published: 2018
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  • Publisher: Unknown

Neuroscience and clinical researchers are increasingly interested in quantitative magnetic resonance imaging (qMRI) due to its sensitivity to micro-structural properties of brain tissue such as axon, myelin, iron and water concentration.We introduce the hMRI-toolbox, an easy-to-use tool openly available on GitHub, for qMRI data handling and processing, presented together with a tutorial and example dataset. This toolbox allows the estimation of high-quality multi-parameter qMRI maps (longitudinal and effective transverse relaxation rates R1 and R? 2, proton density PD and magnetisation transfer MT saturation) that can be used for accurate delineation of subcortical brain structures and calculation of standard and novel MRI biomarkers of tissue microstructure. Embedded in the Statistical Parametric Mapping (SPM) framework, it can be readily combined with existing SPM toolboxes for estimating diffusion MRI parameter maps, and it benefits from the extensive range of established SPM tools for high-accuracy spatial registration and statistical inferences. The hMRI-toolbox is an efficient, robust and simple framework for investigating qMRI data in neuroscience and clinical research.

More Specific Signal Detection in Functional Magnetic Resonance Imaging by False Discovery Rate Control for Hierarchically Structured Systems of Hypotheses
  • Language: en

More Specific Signal Detection in Functional Magnetic Resonance Imaging by False Discovery Rate Control for Hierarchically Structured Systems of Hypotheses

  • Type: Book
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  • Published: 2015
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  • Publisher: Unknown

Signal detection in functional magnetic resonance imaging (fMRI) inherently involves the problem of testing a large number of hypotheses. A popular strategy to address this multiplicity is the control of the false discovery rate (FDR). In this work we consider the case where prior knowledge is available to partition the set of all hypotheses into disjoint subsets or families, e. g., by a-priori knowledge on the functionality of certain regions of interest. If the proportion of true null hypotheses differs between families, this structural information can be used to increase statistical power. We propose a two-stage multiple test procedure which first excludes those families from the analysis...

Structural Adaptive Smoothing in Diffusion Tensor Imaging
  • Language: en
  • Pages: 24

Structural Adaptive Smoothing in Diffusion Tensor Imaging

  • Type: Book
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  • Published: 2008
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  • Publisher: Unknown

None

Modeling High Resolution MRI: Statistical Issues with Low SNR
  • Language: en

Modeling High Resolution MRI: Statistical Issues with Low SNR

  • Type: Book
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  • Published: 2015
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  • Publisher: Unknown

Noise is a common issue for all Magnetic Resonance Imaging (MRI) techniques and obviously leads to variability of the estimates in any model describing the data. A number of special MR sequences as well as increasing spatial resolution in MR experiments further diminish the signal-to-noise ratio (SNR). However, with low SNR the expected signal deviates from its theoretical value. Common modeling approaches therefore lead to a bias in estimated model parameters. Adjustments require an analysis of the data generating process and a characterization of the resulting distribution of the imaging data. We provide an adequate quasi-likelihood approach that employs these characteristics. We elaborate on the effects of typical data preprocessing and analyze the bias effects related to low SNR for the example of the diffusion tensor model in diffusion MRI. We then demonstrate that the problem is relevant even for data from the Human Connectome Project, one of the highest quality diffusion MRI data available so far.