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Targeting the Wnt Pathway in Cancer
Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
The Illinois Bar
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Annual Catalog ...
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The Families of Henry Nail & Mary Keller and Thomas Ray & Elizabeth Pearce
Heinrich Nagel (Henry Nail) (1771-1827), son of Gottlieb Nagel (Caleb Nail) and his wife Margaret of Döffingen, Germany, married 1798 in Rowan Co., North Carolina, Mary Keller (1776-1857), the daughter of Jacob and Barbara Keller. Henry Nail died in Addison Twp., Shelby Co., Indiana. They were parents of thirteen children. Gottlieb Nagel (Caleb Nail) arrived in Pennsylvania in 1754 where he spent the next twenty years. By about 1774 he had left Pennsylvania and moved with at least four of his children to North Carolina. Thomas Ray (1762-1829) was the son of William Ray of Wake Co., N.C. He was born in Granville Co., North Carolina. He married in Wake County Elizabeth Pearce (ca. 1764-1844) in 1783. She was the daughter of Nathan and Nance Weston? Pearce. Family members migrated to Shelby County, Ind. in the early 1820s.
Darwoon Dyreez
In a tiny almost-ghost town at the edge of civilization, a colorful assortment of characters find ingenious and artful ways to adjust to the harsh desert climate and the absence of amenities. The narrator, a transplant from the big city, observes and adapts to the local customs, while trying to contribute innovations of her own. The improbable happenings in this community of misfits range from celebration to black humor to authentic tragedy, all narrated in an invented dialect that immerses the reader in the alternative reality of Darwoon. A work of fiction, based on real events in a real place.
