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Somatic Hypermutation in V-Regions
This book provides critical reviews regarding the process of somatic hypermutation in antibody V genes. Topics covered include the in vivo kinetics of antigen-driven somatic hypermutation in a number of well-studied systems in mice; the instability of lg genes in cultured cells; the key role played in vivo by germinal centers in providing the appropriate "mutational" microenvironment; the types of nucleotide sequence errors generated; the process of hypermutation in pre-arranged V regions expressed in transgenic mice; and a critical evaluation of the status of molecular models proposed to explain hypermutation. Other topics include a detailed review of data from hypervariable retroviral systems, as well as precise studies on the mutagenic potential of various DNA polymerases in vitro. The book will provide indispensable information for immunologists, geneticists, molecular biologists, biochemists, and cell biologists.
Handbook on Immunosenescence
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
