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This volume describes recent research in the field of metalloproteinases (a family of enzymes that can catalyze tissue degradation), in particular their participation in autoimmune diseases such as rheumatoid arthritis, reviewing the latest developments in metalloproteinase inhibitor design and the current status of clinical candidates. This volume is intended not only for those active in research into metalloproteinases but also for those with an interest in inflammatory diseases. Thus it addresses both academic and industrial researchers.
This volume provides new advances regarding the involvement of MMPs in various diseases associated with inflammatory processes. Moreover, the recent development of selective and non selective inhibitors of MMPs give new insights in the relationship between activation of inflammatory cells and tissue remodelling and advise new therapeutics possibilities to the treatment of inflammatory disease. The volume has an international authorship and is written by leading experts in the field.
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The locater lists in alphabetical order every name in all the Social registers and indicates the family's head under which it may be found and the city in which the name appears.
This volume reflects the current state of scientific knowledge about natural climate variability on decade-to-century time scales. It covers a wide range of relevant subjects, including the characteristics of the atmosphere and ocean environments as well as the methods used to describe and analyze them, such as proxy data and numerical models. They clearly demonstrate the range, persistence, and magnitude of climate variability as represented by many different indicators. Not only do natural climate variations have important socioeconomic effects, but they must be better understood before possible anthropogenic effects (from greenhouse gas emissions, for instance) can be evaluated. A topical essay introduces each of the disciplines represented, providing the nonscientist with a perspective on the field and linking the papers to the larger issues in climate research. In its conclusions section, the book evaluates progress in the different areas and makes recommendations for the direction and conduct of future climate research. This book, while consisting of technical papers, is also accessible to the interested layperson.
This book presents new approaches to studying food webs, using practical and policy examples to demonstrate the theory behind ecosystem management decisions.
The health of human populations around the world is constantly changing and the health profiles of most nations in the early twenty-first century global health landscape are unrecognizable compared with those of just a century ago. This book examines and explains these health changes and considers likely future patterns and changes. While the overall picture charted is one of progress and improvement, certain unfortunate regressions and stubbornly persistent health inequalities are equally shown to be part of the evolving patterns of global health. The chapters of the book are organized in three major parts: The first part introduces readers to the principal concepts of global health, and to...
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