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Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. It has been found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This has opened
This book provides a comprehensive overview of the evolution of one of the oldest and best-exposed Archaean cratons on this planet. There is currently a renewed interest in the early Earth, and the Kaapvaal craton has long served as a model for early crustal evolution. This unique multidisciplinary resource features information on geology, tectonics, geochemistry, and geochronology. It offers a wealth of new data on various aspects of the craton as well as contributions on the various crustal units by international specialists.
he Outback is not a place with any definite boundary. When Australians refer to the Outback, they mean the enormous regions of the country that are far away from the sorts of services, transport and facilities that people expect to find in urban areas. Find out who lives in the Outback, how they survive and why they choose to live in one of the harshest but most beautiful places on Earth. - One of the largest wilderness regions left in the world - Cattle stations bigger than countries - Ancient and sparsely populated
An indispensable resource for all levels, this handbook provides up-to-date, in-depth summaries of the most important theories in criminology. Provides original, cutting-edge, and in-depth summaries of the most important theories in criminology Covers the origins and assumptions behind each theory, explores current debates and research, points out knowledge gaps, and offers directions for future research Encompasses theory, research, policy, and practice, with recommendations for further reading at the end of each essay Features discussions of broad issues and topics related to the field, such as the correlates of crime, testing theory, policy, and prediction Clearly and accessibly written by leading scholars in the field as well as up-and-coming scholars
In a field where even experts may find that years have elapsed since they last encountered a child with a given disorder, it is essential for the clinician to have a comprehensive source of practical and highly illustrated information covering the whole spectrum of metabolic disease to refer to. The second edition of this highly regarded book, authored by three of the foremost authorities in pediatric metabolic medicine, fulfils this need by providing an invaluable insight into the problems associated with metabolic diseases. For ease of reference, Atlas of Metabolic Disease is divided into sections of related disorders, such as disorders of amino acid metabolism, lipid storage disorders and...
As clinical management of inherited metabolic diseases (IMDs) has improved, more patients affected by these conditions are surviving into adulthood. This trend, coupled with the widespread recognition that IMDs can present differently and for the first time during adulthood, makes the need for a working knowledge of these diseases more important than ever. Inherited Metabolic Disease in Adults offers an authoritative clinical guide to the adult manifestations of these challenging and myriad conditions. These include both the classic pediatric-onset conditions and a number of new diseases that can manifest at any age. It is the first book to give a clear and concise overview of how this group of conditions affects adult patients, a that topic will become a growing imperative for physicians across primary and specialized care.
Advances in Marine Biology was first published in 1963. Now edited by A.J. Southward (Marine Biological Association, UK), P.A. Tyler (Southampton Oceanography Association, UK), C.M. Young (Harbor Branch Oceanographic Institution, USA) and L.A. Fuiman (University of Texas, USA), the serial publishes in-depth and up-to-date reviews on a wide range of topics which will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, oceanography. Eclectic volumes in the series are supplemented by thematic volumes on such topics as The Biology of Calanoid Copepods. - Includes over 25 tables and 34 illustrations - Covers such topics as reef fishes, crustacea in the arctic and antarctic, fisheries in the Northeast Atlantic, and more - 4 reviews authored by experts in their relevant fields of study
As the Arctic perennial sea ice continues to disappear at an alarming rate, a full understanding of sea ice as a crucial global ecosystem, and the effects of its loss is vital for all those working with and studying global climate change. Building on the success of the previous edition, the second edition of Sea Ice, now much expanded and in full colour throughout, includes six completely new chapters with complete revisions of all the chapters included from the first edition. The Editors, Professor David Thomas and Dr Gerhard Dieckmann have once again drawn together an extremely impressive group of internationally respected contributing authors, ensuring a comprehensive worldwide coverage o...
An asteroid or comet will inevitably strike the Earth some day, and potentially cause great destruction. This volume considers hazards due to collisions with cosmic objects, particularly in light of recent investigations of impacts by the authors. Each chapter, written by an expert, contains an overview of an aspect and new findings in the field. Coverage describes and numerically estimates the main hazardous effects.