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Complement Therapeutics
This book highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis. In addition, complement is often involved in adverse immune reactions to biomaterials, cell and organ transplants or drug delivery systems. Although the complement cascade with its close to 50 extrac...
Corks and Curls
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Advances in Heart Valve Imaging
Valvular heart diseases (VHD) remain one of the leading causes of heart failure and a decrease in life expectancy. Timely diagnosis and management are of utmost importance for this subgroup of patients. Recent advances in cardiac imaging and transcatheter therapeutic approaches have led to the development of the term “Heart Team” and the new sub-specialty of “interventional Echocardiographer”. Through the routine use of advanced echocardiography (strain and 3D imaging) and all other modalities, such as CT and CMR, we have better recognized the mechanisms of valvular abnormalities and we have provided the option to expand the transcatheter therapies. With this Research Topic, we seek to provide an overview of the latest advances in imaging techniques on Valvular Diseases, such as advanced Echocardiographic tools, Cardiac CT and MR, and PET/CT-PET/MR imaging. We also seek to emphasize how these new techniques can support diagnosis and help treat difficult cases that go beyond our routine and cover the up-to-date imaging approach of the “Heart Team”.
Pediatric Orthopedic Imaging
This book is an indispensable reference for pediatric and musculoskeletal radiologists, as well as orthopedic surgeons. It offers in depth analysis of pediatric orthopedic imaging, covering normal and aberrant development as well as both common and unusual pediatric disorders. Chapters on the spine, shoulder, elbow, hand and wrist, hip and pelvis, lower extremity, and foot and ankle address site-specific congenital and acquired lesions. Subsequent chapters cover generalized orthopedic diseases such as neurofibromatosis and osteogenesis imperfecta, infectious processes, neuromuscular diseases, musculoskeletal tumors, trauma, and orthopedic procedures. The chapters review associated epidemiology, clinical presentation and evolution, treatment, and differential diagnoses, with in-depht analysis of imaging characteristics. With more than 1800 images, high-quality MRI, CT, and US examples complement the radiographs of a broad variety of musculoskeletal disorders.
M-Health
M-health can be defined as the ‘emerging mobile communications and network technologies for healthcare systems.' This book paves the path toward understanding the future of m-health technologies and services and also introducing the impact of mobility on existing e-health and commercial telemedical systems. M-Health: Emerging Mobile Health Systems presents a new and forward-looking source of information that explores the present and future trends in the applications of current and emerging wireless communication and network technologies for different healthcare scenaria. It also provides a discovery path on the synergies between the 2.5G and 3G systems and other relevant computing and info...
Artificial Neural Networks - ICANN 2006
The two-volume set LNCS 4131 and LNCS 4132 constitutes the refereed proceedings of the 16th International Conference on Artificial Neural Networks, ICANN 2006. The set presents 208 revised full papers, carefully reviewed and selected from 475 submissions. This first volume presents 103 papers, organized in topical sections on feature selection and dimension reduction for regression, learning algorithms, advances in neural network learning methods, ensemble learning, hybrid architectures, and more.
Introduction to Nonextensive Statistical Mechanics
This book focuses on nonextensive statistical mechanics, a current generalization of Boltzmann-Gibbs (BG) statistical mechanics. Conceived nearly 150 years ago by Maxwell, Boltzmann and Gibbs, the BG theory, one of the greatest monuments of contemporary physics, exhibits many impressive successes in physics, chemistry, mathematics, and computational sciences. Presently, several thousands of publications by scientists around the world have been dedicated to its nonextensive generalization. A variety of applications have emerged in complex systems and its mathematical grounding is by now well advanced. Since the first edition release thirteen years ago, there has been a vast amount of new resu...
