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Statistical Population Genomics
This open access volume presents state-of-the-art inference methods in population genomics, focusing on data analysis based on rigorous statistical techniques. After introducing general concepts related to the biology of genomes and their evolution, the book covers state-of-the-art methods for the analysis of genomes in populations, including demography inference, population structure analysis and detection of selection, using both model-based inference and simulation procedures. Last but not least, it offers an overview of the current knowledge acquired by applying such methods to a large variety of eukaryotic organisms. Written in the highly successful Methods in Molecular Biology series f...
Approaching Complex Diseases
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor eff...
Rabbit Hole
'I fell down Rabbit Hole in an obsessive spiral' KATE REED PETTY, AUTHOR OF TRUE STORY 'A mindblowing debut' HEATHER DARWENT, author of THE THINGS WE DO TO OUR FRIENDS ________________________________ A deliciously dark and twisted debut about family secrets, true crime, and destructive obsession – by a striking new talent Teddy Angstrom is no stranger to morbid public interest in her family's tragedies. And when her father dies suddenly, ten years to the day after her sister Angie's disappearance, she intends to maintain as much privacy as she always has. Clearing out her father's office, however, Teddy discovers her father's double life: a decade-long investigation into wild conspiracies...
Gene Network Inference
This book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the chapter authors received the same datasets to evaluate the performance of their method to better understand which algorithms are most useful for obtaining reliable models from SG datasets. The knowledge gained from this benchmarking study will ultimately allow these algorithms to be used with confidence for SG studies e.g. of complex human diseases or food crop improvement. The book is primarily intended for researchers with a background in the life sciences, not for computer scientists or statisticians.
Fodder Oats
Background to fodder oats worldwide; Fodder oats; an overview; Fodder oats in North America; Fodder oats: an overview for South America; Fodder oats in the Maghreb; Fodder oats in Pakistan; Fodder oats in the Himalayas; Fodder oats in China; Fodder oats in New Zealand and Australia- history, production and potential; Fodder oats in Europe; Oat diseases and their control; Perspectives for fodder oats.
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