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This book focuses on the mechanical properties of cells, discussing the basic concepts and processes in the fields of immunology, biology, and biochemistry. It introduces and explains state-of-the-art biophysical methods and examines the role of mechanical properties in the cell/protein interaction with the connective tissue microenvironment. The book presents a unique perspective on cellular mechanics and biophysics by combining the mechanical, biological, physical, biochemical, medical, and immunological views, highlighting the importance of the mechanical properties of cells and biophysical measurement methods. The book guides readers through the complex and growing field of cellular mechanics and biophysics, connecting and discussing research findings from different fields such as biology, cell biology, immunology, physics, and medicine. Featuring suggestions for further reading throughout and addressing a wide selection of biophysical topics, this book is an indispensable guide for graduate and advanced undergraduate students in the fields of cellular mechanics and biophysics.
The study of evolutionary adaptation returns to the center stage of biology with this important volume. This innovative treatise discusses new developments in adaptation, with new methods, and new theoretical foundations, achievements, and prospects for a rich intellectual future. It is an insightful reintroduction to the themes that Darwin and his successors regarded as central to any profound understanding of biology.
This book is devoted to the pathophysiology of the microcirculation, an intensely studied area of the circulatory system. Featuring contributions from 29 top investigators in the field, the book begins with an introduction to the general structure of the normal microvascular system, with special emphasis on the characteristics of blood vessel segments collectively comprising the system. Significant areas covered in the book include angiogenesis, neoplasias, hypertension, shock, ischemia/reperfusion, diabetes, immunologic injury, and thermal injury. It also covers the effects of aging and environmental factors on the microcirculation-topics not often examined in depth. More than 80 figures and tables illustrate key concepts throughout the book.
The general perception of the west midlands region in the Roman period is that it was a backwater compared to the militarized frontier zone of the north, or the south of Britain where Roman culture took root early – in cities like Colchester, London ,and St Albans – and lingered late at cities like Cirencester and Bath with their rich, late Roman villa culture. The west midlands region captures the transition between these two areas of the ‘military’ north and ‘civilized’ south. Where it differed, and why, are important questions in understanding the regional diversity of Roman Britain. They are addressed by this volume which details the archaeology of the Roman period for each o...
The birth of bacterial genomics since the mid-1990s brought withit several conceptual modifications and wholly new controversies. Working beyond the scope of the neo-Darwinian evolutionary synthesis, a group of leading microbial evolutionists addresses the following and related issues, often with markedly varied viewpoints: · Did the eukaryotic nucleus, cytoskeleton and cilia also orginate from symbiosis? · Do the current scenarios about he origin of mitochondria and plastids require revision? · What is the extent of lateral gene transfer (between "species") among bacteria? · Does the rDNA phylogenetic tree still stand in the age of genomics? · Is the course of the first 3 billion years of evolution even knowable?
This monograph examines the concept of Jesus’ perfection in the Epistle to the Hebrews in relation to the broader theological themes of divine beneficence and divine “philanthropia”. Three times in Hebrews Jesus is described as being perfected (Hebrews 2:10, 5:9, 7:28), and in two of these instances (Hebrews 2:10, 5:8-9) the author explicitly links the theme of Jesus’ suffering to the content of his perfection. By examining representative selections of Greek non-literary papyri, this study argues that the customary application of the Greek verb τελειόω to denote the idea of legal notarization of a public document suggests the more comprehensive idea of official, definitive att...
Epigenetics is one of the most exciting and rapidly developing areas of modern genetics with applications in many disciplines from medicine to agriculture. The most common form of epigenetic modification is DNA methylation, which plays a key role in fundamental developmental processes such as embryogenesis and also in the response of organisms to a wide range of environmental stimuli. Indeed, epigenetics is increasing regarded as one of the major mechanisms used by animals and plants to modulate their genome and its expression to adapt to a wide range of environmental factors. This book brings together a group of experts at the cutting edge of research into DNA methylation and highlights recent advances in methodology and knowledge of underlying mechanisms of this most important of genetic processes. The reader will gain an understanding of the impact, significance and recent advances within the field of epigenetics with a focus on DNA methylation.