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Hardbound. On the basis of significant advances in the molecular, cellular and behavioural fields in the past decade, there has been a great increase in our knowledge of the biological action of adenosine and its related compounds in the nervous system.These proceedings survey the expansion of ideas and development of potential applications and bring together the up-to-date knowledge and in-depth understanding of adenosine, a highly significant neuromodulator. The objectives of the symposium were not encyclopedic, but rather catalytic. Various fields of research from molecular biology to clinical therapeutics including several topics on the extraneuronal action of adenosine are covered.
A Jupiter jeges holdján, az Europán valami él. Robotszondák a fagyos felszín alatt egy ősi, folyton változó járatrendszerre bukkannak, melynek falait ismeretlen írás hieroglifái borítják. Egy rendkívüli tehetséggel megáldott mérnöknő, Alexis Vonderach részvételével kutatóexpedíció indul, hogy megállapítsa, megérett-e a helyzet a kapcsolatfelvételre. Amikor azonban a tudósok leereszkednek a jégvilág sötétségébe, olyasvalamivel találják szembe magukat, amire egyáltalán nem számítottak. És talán jobb lenne, ha a kapcsolatfelvétel helyett a lehető legmesszebbre elkerülnék. A Philip K. Dick-díjra is jelölt amerikai szerző hihetetlenül izgal...
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An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.
The genealogical importance of Lancaster, Pennsylvania, cannot be overstated. Organized in 1729, Lancaster was the parent of thirty other counties, and therefore many early records of Pennsylvania ultimately date back to Lancaster County. Moreover, few U. S. counties hosted such a variety of peoples and religions. Throngs of immigrants came to Lancaster County in the 18th century, the two largest groups being the Scotch-Irish and the Germans. Religious denominations included Mennonites, Quakers, Amish, Episcopalians, Presbyterians, German Baptists, Lutherans, German Reformed, Moravians, Catholics, the Universalists, the Evangelical Association, and more. I. Daniel Rupp's "History of Lancaster County, Pennsylvania" documents the origins and development of this hotbed of Pennsylvania genealogy.
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Presents short stories of fantasy and horror which are set either in the future or in unknown worlds.
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