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Antivirals for Emerging Viruses: Vaccines and Therapeutics
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Understanding the Materno-Fetal Interface During Microbial Infections
Pregnancy is a physiologically and immunologically challenging health state. Immunological and physiological changes throughout the course of pregnancy make pregnant women usually susceptible to infection with microbial agents. Infections with pathogens during pregnancy can have devastating consequences to both the fetus and his/her mother. These infections are linked with adverse pregnancy outcomes. Infections with parasites, viruses, or bacteria can be associated with maternal anemia, abortion, intrauterine growth retardation, preterm delivery, fetal morbidity and high risk of mortality during the first years of life. Despite these significant consequences and complications associated with...
Virus Entry Inhibitors
This book focuses on the important discoveries of the small molecule-, peptide-, and protein-based virus entry inhibitors and discusses advance of the development of different type of virus entry inhibitors as a novel class of antiviral drugs for treatment and prevention of viral infection. It includes entry inhibitors of HIV,HeV, NiV, RSV, EBOV, HCoV, HBV, HCV, HDV, HPV, flavivirus and influenza virus, so on. This book aims at providing an updated knowledge on virus entry inhibitors.
Management and Sustainability in the Belt and Road
China’s Belt and Road Initiatives (BRI) is an ambitious infrastructure project conceived in 2013 by President Xi Jinping with development and investment initiatives stretching from Asia and Europe that reflect the original Silk Road with business networks through countries such as Afghanistan, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan, as well as India and Pakistan, spanning a route of more than 4,000 miles and history that can be dated back more than 2,200 years. Given the background of China’s unique approach in fighting COVID-19, and against the backdrop of sluggish economic growth, innovation, and management, sustainable development of BRI will be the key and t...
Preventing the Next Pandemic
The last five years saw a significant return of epidemic infectious disease, culminating in COVID-19. In our new post–COVID-19 world, how do we prevent future illnesses by expanding scientific and vaccine diplomacy and cooperation, especially to combat the problems that humans have brought on ourselves? Modern diseases and viruses have been spurred anew by war and conflict as well as shifting poverty, urbanization, climate change, and a new troubling anti-science/anti-vaccination outlook. From such twenty-first-century forces, we have seen declines in previous global health gains, with sharp increases in vaccine-preventable and neglected diseases on the Arabian Peninsula, in Venezuela, in ...
Deception
Senator Rand Paul was on to Anthony Fauci from the start. Wielding previously unimaginable power, Fauci misled the country about the origins of the Covid pandemic and shut down scientific dissent. One of the few leaders who dared to challenge "America’s Doctor" was Senator Rand Paul, himself a physician. Deception is his indictment of the catastrophic failures of the public health bureaucracy during the pandemic. Senator Paul presents the evidence that: The Covid virus was likely the product of gain-of-function research at the Wuhan lab in China—research funded in part by the U.S. government. Taxpayer dollars for that research were deceptively funneled to Wuhan without the required regul...
How to Make a Vaccine
Understand the Virus -- Explore the Immune System -- Discover a Vaccine -- Develop Vaccines -- Evaluate the Contenders -- Don't Count on the Magic Bullet -- Overcome the Hurdles -- Embrace Many Solutions.
Learning from the COVID-19 Pandemic
COVID-19 was first identified in Wuhan City in December 2019 and spread throughout Hubei Province and other parts of China. After causing significant morbidity and mortality in China, by February 2020, it had spread to numerous other countries, infecting millions of people and causing a large number of deaths across the world. The COVID-19 pandemic put a burden on almost all areas of the world including healthcare systems, education, industry, travel, etc. The pandemic revealed the vulnerability of the world’s healthcare systems and affected healthcare personnel significantly. The virus is able to attack not only the respiratory tract, but almost all the organs including the brain. Impacts...
Multi-Pronged Omics Technologies to Understand COVID-19
"COVID-19 and Omics Technologies" is a comprehensive, integrative assessment of recent information and knowledge collected on SARS-CoV-2 and COVID-19 during the pandemic based on omics technologies. It demonstrates how omics technologies could better investigate the infectious disease and propose solutions to the current concerns. The value of multi-omics technologies in understanding disease etiology and host response, discovering infection biomarkers and illness prediction, identifying vaccine candidates, discovering therapeutic targets, and tracing pathogen evolution is discussed in this book. These factors combine to make it a valuable resource to enhance understanding of both "Omics tec...
