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Novel Synthetic Drugs in Migraine
Published in the series Headache, endorsed by the European Headache Federation, this is the first book on the novel synthetic treatment of migraine with ditans (lasmiditan) and gepants (atogepant, ubrogepant, rimegepant, vazegepant). These drugs will provide additional options for people with migraine put at risk of side effects by other medications or with unsatisfactory response to previous drugs. There is now a sufficient amount of literature published to interest a wide multidisciplinary readership (general physicians, general neurologists, clinical psychologists, neurologists in training, and medical students) facing every day this burdensome disorder in their clinical practice. The book aims therefore at offering an overview of these new drugs for both acute and prophylactic treatments of migraine, covering studies on clinical evidence, tolerability, and the different stages of clinical development.
Cerebral Blood Flow and Metabolism
Written and edited by the world's foremost authorities, the Second Edition of this landmark work is a current, comprehensive reference on cerebral blood flow and metabolism. The book covers the entire field in a systematic and coherent way and synthesizes the diverse body of basic science and clinical literature. The reader will gain a complete understanding of the anatomical, physiological, and pharmacological bases of the cerebral circulation, its regulation in health and disease, and the pathophysiological disturbances occurring in cerebrovascular disorders. Coverage includes stimulating discussions of future directions for research and therapeutic intervention.
Vascular Innervation and Receptor Mechanisms
Vascular Innervation and Receptor Mechanisms ...
Headache Pathogenesis
The contributors to this volume explore the role of several messenger molecules in the pathogenesis of migraine, tension-type headache, and cluster headache. Coverage includes extensive studies of these molecules and their receptors in the cranial blood vessels, as well as measurements in patients during actual migraine and other headache attacks. The findings presented are important to the development of anti-migraine drugs targeted to specific receptors.
Basic Mechanisms of Headache
As we learn more about the the basic mechanisms of headache, it becomes obvious that they are indeed complex, and that no single factor will ever be found which alone can explain migraine or other primary headaches. It is imperative to improve the classification and diagnostic criteria of headache disorders and to study patients in a more systematic way in order to gather reliable information about physiological and biochemical abormalities occurring during headache attacks. The purpose of this book is to present anatomical, physiological and pharmacological knowledge relevant to headache along with actual studies of pathophysiological events in headache patients, thereby bridging the gap between basic science and clinical science.
Migraine and Headache Pathophysiology
Migraine Pathophysiology provides an overview of current and accepted methodologies for the experimental study of migraine of primary headache syndromes in the laboratory in animals and man. It gives the reader a view of the current status and direct basic scientists and the pharmaceutical industry in choosing experimental situations for developing new therapies.
