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O comprometimento com a evolução do próximo é imprescindível para alcançar a consolidação efetiva do seu próprio desenvolvimento Sinto-me privilegiada por estar em contato com líderes dos mais diversos segmentos do mercado, todos engajados na agenda da Educação. Hoje somos mais de 400 líderes engajados, levando inspiração para as gerações de jovens, compartilhando suas experiências e aprendizados de vida. Atualmente, temos 50 milhões de jovens (segundo o IBGE), dos quais 35% não querem trabalhar ou estudar, conhecidos como a geração ""nem-nem"", e 56% estão desempregados. Ao ter acesso a esses dados, senti-me na obrigação de oferecer novas referências e inspiração...
Cet ouvrage est une réédition numérique d’un livre paru au XXe siècle, désormais indisponible dans son format d’origine.
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Advances in RNA-sequencing (RNA-seq) technologies have provided an unprecedented opportunity to explore the gene expression landscape across individuals, tissues, and environments by efficiently profiling the RNA sequences present in the samples. When a reference genome sequence or a transcriptome of the sample is available, mapping-based RNA-seq analysis protocols align the RNA-seq reads to the reference sequences, identify novel transcripts, and quantify the abundance of expressed transcripts.The reads that fail to map to the human reference, known as unmapped reads, are a large and often overlooked output of standard RNA-seq analyses. Even in carefully executed experiments, the unmapped r...
,This is the updated, widely revised, restructured and expanded third edition of Léna et al.'s successful work Observational Astrophysics. It presents a synthesis on tools and methods of observational astrophysics of the early 21st century. Written specifically for astrophysicists and graduate students, this textbook focuses on fundamental and sometimes practical limitations on the ultimate performance that an astronomical system may reach, rather than presenting particular systems in detail. In little more than a decade there has been extraordinary progress in imaging and detection technologies, in the fields of adaptive optics, optical interferometry, in the sub-millimetre waveband, obser...
This collection of papers offers a timely snapshot of helio- and asteroseismology in the era when SOHO/MDI instrument is about to be replaced by SDO/HMI and when the CoRoT space mission is yielding its first long-duration light curves of thousands of stars.
Multiple dysfunctions take place in the B cell compartment during HIV-1 infection, comprising depletion of resting memory B cells carrying serological memory to vaccines and previously met pathogens. In addition, population of B cells characterized by the expression of exhaustion markers are enlarged during HIV-1 infection. Antibodies with the capacity to neutralize a broad range of HIV-1 isolates can be detected only in a minority of infected patients, after a year or more from acute infection. An open question is whether the inability of producing neutralizing HIV-1 antibodies is somehow linked to the B cell immunopathology observed in patients. In this research topic we invited scientists...
For the last twenty years astronomy has been developing dramatically. Until the nineteen-fifties, telescopes, spectrometers, and photographic plates consti tuted a relatively simple set of tools which had been refined to a high degree of perfection by the joint efforts of physicists and astronomers. Indeed these tools helped at the birth of modern astrophysics: the discovery of the expan sion of the Universe. Then came radioastronomy and the advent of electronics; the last thirty years have seen the application to astrophysics of a wealth of new experimental techniques, based on the most advanced fields of physics, and a constant interchange of ideas between physicists and astronomers. Last,...