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Glutamate Receptors in Peripheral Tissue
Glutamate receptors (GluRs) in the central nervous system have been the subject of intense investigations for several decades, providing new avenues for the understanding of excitatory neurotransmission, excitotoxicity, mechanisms of injury, and therapeutics for several acute neurological conditions, such as brain trauma, and for neurodegenerative and neuropsychiatric disorders including addictions, Alzheimer disease, etc. Evidences of GluRs beyond the central nervous system were first reported in the early 1990s. When the idea of this book was conceived, the knowledge, specificity, and functional significance of GluRs in peripheral tissues was still in its embryonic stage. From our perspect...
Excitatory Amino Acids
This past decade has led to many significant advances in the understanding of the function of excitatory amino acids in synaptic transmission. The cloning of the ionotropic and metabotropic glutamate receptor families of receptor proteins has produced new strategies for the pharmacological modulation of glutamate transmission. The engineering of transgenic animals with modified expression of receptor proteins has created new insights into the function, dysfunction and possible pathology causally related to glutamate receptors. Advances in the pharmacology of glutamate receptors has led to clinical research addressing multiple therapeutic applications of drugs that act on excitatory amino acid systems. A number of NMDA receptor anatagonists have now been studied in humans. AMPA/kainate and metabotropic receptor active compounds have left the preclinical realms of research and have moved towards or are in the clinic.
Virtual ADMET Assessment in Target Selection and Maturation
A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the advent of combinatorial chemistry. This volume summarizes discussions of three aspects of modern drug discovery, that is, priority for targets, early ADMET assessment, and in silico screening.
Excitatory Amino Acids and Second Messenger Systems
This book deals with the mechanisms through which glutamate, the principal excitatory neurotransmitter in the mammalian central nervous system, modifies neuronal membrane functions and intraneuronal functions. Discussed are the hypothesis that the glutamate receptor signal may be processed by archidonic acid, nitric oxide, Ca 2+ and protein kinases. A key routefor glutamate receptors in synaptic plasticity and neuronal degeneration is beeing increasingly recognized. This is one of the most important new areas of endeavor by neurobiologists. The book, written by some of the most wellknown scientists in this field, provides a comprehensive reviewof conceptual approaches along with experiments showing a link between excitation mediated by glutamate and second messenger systems.
Etiopathogenesis
In 1991, a small annual meeting named "International Winter Conference on Neurodegeneration (lWCN)" was established; the aim of this meeting is to review the neurodegenerative disorders and to attempt to explore how progress might be made in this field, as the neurodegenerative disorders have been emerging to be one of the major causes of morbidity and mortality in modern societies. The first meeting took place in Seefeld, Austria, in February 1992; the topics for the first IWCN were chosen to provide a broad foundation of clinical science, which included the problem of aging, classification of neurodegenerative disorders and of Alzheimer's dis natural history, pathology, and clinical neurol...
Social Violence in the Prehispanic American Southwest
Spontaneous acts of violence born of human emotions like anger or greed are probably universal, but social violence—violence resulting from social relationships within and between groups of people—is a much more complex issue with implications beyond archaeology. Recent research has generated multiple interpretations about the forms, intensity, and underlying causes of social violence in the ancient Southwest. Deborah L. Nichols and Patricia L. Crown have gathered nine contributions from a variety of disciplines to examine social violence in the prehispanic American Southwest. Not only offering specific case studies but also delving into theoretical aspects, this volume looks at archaeol...
Thinking about Cognition: Concepts, Targets and Therapeutics
100 Years after the discovery of Alzheimer’s disease, neurological diseases and psychiatric disorders represent the largest and fastest growing unmet medical market with 2 billion affected people worldwide. Life expectancy of humans continues to increase, and the world population is aging. Advanced age may lead to deterioration of cognitive functions of the brain. There seems to be consensus that on the background of aging, several factors may render humans prone to dementia. Psychiatric and neurological disorders such as schizophrenia, bipolar disorder or Parkinson’s disease may contribute to development of dementia. More people today are looking for help regarding their learning and me...
