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Early Diagnosis of Alzheimer’s Disease
Drs. Leonard Scinto and Kirk Daffner provide a comprehensive survey of new diagnostic approaches to Alzheimer's disease. The authoritative contributors critically survey the most promising current research on early diagnostic markers for Alzheimer's disease, including the elucidation of changes in the brain revealed by structural and functional neuroimaging, as well as the characteristic patterns of cognitive decline that are documented by sensitive neuropsychological tests, various genetic markers, and biological assays. Early Diagnosis of Alzheimer's Disease illuminates the complex issues surrounding the search for early markers of this increasingly widespread disease. It will establish a new standard reference guide for all those working with Alzheimer's patients.
Parkinson's Disease and Nonmotor Dysfunction
Parkinson’s Disease and Nonmotor Dysfunction fills a major gap in the current rapidly growing body of knowledge concerning Parkinson’s disease. Drs. Pfeiffer and Bodis-Wollner have correctly perceived that many nonmotor features of Parkinson’s disease are given insufficient attention in the medical literature. Unfortunately, they are often also given insufficient attention by the practicing neurologists who see these patients. As recently pointed out, there is clearly much more to Parkinson’s disease than depletion of the nigrostriatal dopamine system (1). Parkinson’s disease (not just m- tiple system atrophy) is a multisystem disorder, both pathologically and in its clinical manif...
Status Epilepticus
A panel of senior clinicians critically reviews the many forms of status epilepticus (SE), their causes, manifestations, methods of diagnosis, and appropriate treatments. The emphasis is on the disease as encountered by the clinician in the field and the importance of correct recognition and diagnosis. The authors provide for each form of SE the underlying genetic, biological, and developmental background, the pathophysiological processes, as well as the precipitating factors that lead to an episode. For the difficult problem of diagnosing nonconvulsive SE, they offer detailed syndrome classifications, differential diagnoses, descriptions of seizure "imitators," notes on unusual behavioral and cognitive manifestations, and carefully delineated clinical presentations. Additional highlights include striking EEG reproductions that provide classic examples of patients in SE, SE in very young children and neonates, and an analysis of the cellular physiology and processes occurring during SE.
Neurological and Psychiatric Disorders
A comprehensive, systematic, and advanced review of the scientific, preclinical, and clinical aspects of several major mental illnesses. The illnesses covered range from neurological disorders including Alzheimer's disease, Huntington's disease, and Parkinson's disease, to psychiatric disorders including schizophrenia, autism spectrum disorders, Tourette's syndrome and tic disorders, obsessive-compulsive disorder, unipolar depression, bipolar disorder, and attention deficit hyperactivity disorder. For each disorder, the authors uniformly discuss its incidence and prevalence, etiology, molecular targets and mechanisms of action, brain structures and pathways, animal models, signs and symptoms, genetics, treatments, and related medical terminology.
Inflammatory Disorders of the Nervous System
A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.
Thrombolytic Therapy for Acute Stroke
It often takes time for a new therapeutic modality to mature into an accepted treatment option. After initial approval, new drugs, devices, and procedures all go through this process until they become “vetted” by the scientific community as well as the medical community at large. Thrombolysis for treatment of stroke is no exception. Thrombolytic Therapy for Acute Stroke, Second Edition comes four years after the first edition and provides a very comprehensive, updated perspective on the use of intravenous rt-TPA in acute stroke. The authors provide longer term follow-up on the pivotal clinical trials that led to Food and Drug Administration approval, data concerning phase 4 trials in lar...
Atypical Parkinsonian Disorders
A comprehensive review of what is known not only about the cause and treatment of atypical parksonian disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors cover the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions.
Psychiatry for Neurologists
A panel of international psychiatrists, neurologists, clinical psychologists, and neuropsychiatrists review for the clinical neurologist those aspects of psychiatry that impact the management of neurological disorders. On the one hand, the authors illuminate the neurological aspects of such psychiatric disorders as depression, anxiety disorders, schizophrenia, hysteria, catatonia, addictions, and personality disorders. On the other hand, they also explain in detail the psychiatric evaluation of the neurological patient and discuss the behavioral aspects of the major neurological disorders, including psychiatric complications of dementia and stroke, neuromuscular disorders, the psychiatric aspects of Parkinson's disease, epilepsy, Huntington's disease, Tourette's syndrome, and multiple sclerosis. Comprehensive and timely, Psychiatry for Neurologists helps to close the artificial gap separating neurology and psychiatry so that neurologists feel comfortable managing the psychiatric aspects of the neurological disorders they treat.
Seizures in Critical Care
A panel of international ICU and epilepsy physicians and researchers detail the epileptic phenomena that occur in the complex environment of the ICU. Focusing on the central nervous system, the authors systematically examine the most up-to-date evidenced-based data regarding ICU seizures, including their most frequent causes, their pathophysiology, their clinical presentation, and the diagnostic evaluation needed to confirm their presence. They also discuss the challenges and specifics of the management of ICU seizures, reviewing the new antiepileptics and their interaction with other ICU medications, drugs with epileptogenic properties used in the ICU, and the role of the new enterally available antiepileptics in treating seizures. Numerous tables summarize drug interactions, neuroimages reveal common ICU seizure etiologies, and multiple electroencephalographic recordings demonstrate clinical or subclinical seizures in ICU patients.
