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Vols. for 1921-1969 include annual bibliography, called 1921-1955, American bibliography; 1956-1963, Annual bibliography; 1964-1968, MLA international bibliography.
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacol...
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Pechè pwason an ak madanm li
This book explores the tremendous impact of Jesuit Father François Annat (1590-1670), a French government appointee at Court. His religious superiors approved of his taking on this work for the Crown. He served as Minister for Religious Affairs, or Royal Confessor or ‘keeper of the king’s conscience’, for Louis XIV. During Annat’s confessorate of sixteen years, no internal conflict in the Gallican Church was so strong as the Jansenist controversy. Today everything seems different, as revisionist history has viewed Jansenism as an orthodox Augustinian alternative to explain the Catholic Faith, in contrast to the prevailing Spanish Molinism and Suarezianism, whose roots were in Thomism and Aristotle. There was intense internal struggle within the French Church to devise a legal formulary that might decrease the strength of Jansenism. The present work examines the life of Annat in all of its complexities, a life which may have been forgotten by history if not for the celebrated literary figure Blaise Pascal, who was a committed Jansenist and foe of François Annat.
The volume contains both general and research papers. Among the first ones are papers showing recent and original developments or methods in subjects such as resolution of singularities, D-module theory, singularities of maps and geometry of curves. The research papers deal on topics related to, or close to, those listed_above. The contributions are organized in three parts according to their contents. Part I presents a set of papers on resolution of singularities, a topic of renewed activity. It deals with important topics of current interest, such as canonical, algorithmic, combinatorial and graphical procedures (Villamayor, Oka, Marijmin), as well as special results on desingularization i...