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This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes...
The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.
This book is a collection of eight articles, of which seven are reviews and one is a research paper, that together form a Special Issue that describes the roles that long noncoding RNAs (lncRNA) play in gene regulation at a post-transcriptional level.
Containing ballads of martial heroism, tales of tragic lovers and visions of the nature of the world, Long Narrative Songs from the Mongghul of Northeast Tibet: Texts in Mongghul, Chinese, and English is a rich repository of songs collected amongst the Mongghul of the Seven Valleys, on the northeast Tibetan Plateau in western China. These songs represent the apogee of Mongghul oral literature, and they provide valuable insights into the lives of Mongghul people—their hopes, dreams, and worries. They bear testimony to the impressive plurilingual repertoire commanded by some Mongghul singers: the original texts in Tibetan, Mongghul, and Chinese are here presented in Mongghul, Chinese, and En...
Manual for Long-Covid and Post-Vac: How do they work, which are the problems? How can they be detected and diagnosed? Which investigations and lab markers are crucial? What can we learn from them? Which tools do we have, to get back our health - may they be drugs, supplements, micronutrients, nutrition or instrument-based? The book provides comprehensive but comprehensible explanations, protocols and procedures.
Understanding the Behavioral and Medical Impact of Long COVID serves to expand the research around the illness in order to enable health care researchers and practitioners to address the questions that are imperative to individuals suffering from this condition. Through its multi-faceted approach, the book puts forth a maturation of research and interventions that are theoretically sound, empirically valid, innovative, and creative in the Long COVID area. As a scholarly and scientific compilation of Long COVID symptoms and related disorders, this book offers unparalleled insight into the critical developments across medical areas treating this illness. It helps to fill the space that the pan...
Long acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability. An intriguing variety of technologies have been developed to provide long acting injections and implants. Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient. This book surveys and summarizes the field. Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications fo...
A collection of poetry and prose on politics, protest, disillusion, and introspection tempered with a liberating balm of peace and reconciliation. Writing is meant to provoke and question the order of things while revealing a humbling recognition of stubborn reality and the struggle we endure to form a more acceptable life and ultimate deliverance.