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Untersuchung des tumorrelevanten Proteins Survivin
  • Language: de
  • Pages: 63

Untersuchung des tumorrelevanten Proteins Survivin

Survivin ist in nahezu allen malignen Tumorerkrankungen überexprimiert und aufgrund seiner dualen Rolle als Apoptose-Inhibitor und Zellzyklus-Regulator an zwei entscheidenden Prozessen der Onkogenese beteiligt. Für die Ausübung beider biologischer Funktionen ist die Interaktion von seinem Kernexportsignal mit dem Exportrezeptor Crm1 essentiell, weshalb die gezielte Inhibition dieser Interaktion einen guten Angriffspunkt für die Krebstherapie darstellt. Lisa Oelschläger analysiert die Effekte supramolekularer Liganden auf die Funktion von Survivin, die mit ihrer hohen Affinität gegenüber oberflächenexponierten Lysin- und Arginin-Seitenketten einen vielversprechenden neuen Ansatz zur gezielten Inhibition der Survivin-Crm1-Interaktion darstellen.

Tour Book
  • Language: en
  • Pages: 512

Tour Book

  • Type: Book
  • -
  • Published: 1992
  • -
  • Publisher: Unknown

None

Europe Travel Guide
  • Language: en
  • Pages: 620

Europe Travel Guide

  • Type: Book
  • -
  • Published: 1993
  • -
  • Publisher: Unknown

None

Adressbuch der Stadt Karlsruhe
  • Language: de
  • Pages: 1280

Adressbuch der Stadt Karlsruhe

  • Type: Book
  • -
  • Published: 1945
  • -
  • Publisher: Unknown

None

Paper Butterflies
  • Language: en
  • Pages: 213

Paper Butterflies

June's life at home with her stepmother and stepsister is a dark one—and a secret one. Not even her dad knows the truth, and she can't find the words to tell anyone else. She's trapped like a butterfly in a net. Then June meets Blister, a boy from a large, loving, chaotic family. In him, she finds a glimmer of hope that perhaps she can find a way to fly far, far away. Because she deserves her freedom. Doesn't she?

Whitley County and Its Families, 1835-1995
  • Language: en
  • Pages: 241

Whitley County and Its Families, 1835-1995

None

National Library of Medicine Catalog
  • Language: en
  • Pages: 892

National Library of Medicine Catalog

  • Type: Book
  • -
  • Published: 1960
  • -
  • Publisher: Unknown

None

Iowa Volleyball
  • Language: en
  • Pages: 56

Iowa Volleyball

  • Type: Book
  • -
  • Published: 1998
  • -
  • Publisher: Unknown

None

Southern Beltway Transportation Project, I-79 to Mon/Fayette Expressway (PA Turnpike 43), Washington County
  • Language: en
  • Pages: 698
My Grampy Can't Walk
  • Language: en

My Grampy Can't Walk

  • Type: Book
  • -
  • Published: 2008-05-15
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  • Publisher: Vanita Books

Grampy has multiple sclerosis and uses a wheelchair, but that doesn't keep him from doing some pretty spectacular things with his grandchildren in this inspiring and enlightening story.