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The National Institute of Mental Health (NIMH) AIDS Program is the fourth largest acquired immune deficiency syndrome (AIDS) program within the National Institutes of Health (NIH). Since 1983, our program's contributions have concentrated on two major areas. The first has been to develop effective strategies to prevent or reduce behaviors that place individuals at risk for human immunodeficiency virus type 1 (HIV-1) infection. The second has been to support and foster research to enhance our understanding of the profound impact of H IV-1 infection on the central nervous system (eNS). The brain appears to be a prime target of the virus and may serve as a reservoir for the virus. Post mortem e...
Assesses the current state of neuroscience & identifies & makes recommendations for further research opportunities. Chapters are devoted to: neural development, functional organization of the central nervous system & the integration of information, neurotransmission, neural regulation of behavior, cognitive neuroscience & neural plasticity, neuropsychopharmacology, neuroimmunology & neurovirology, advanced technologies for neuroscience, & neural basis of psychopathology. Extensive bibliography. Photos, charts & tables.
Cytokines had been characterized in the early eighties as communication mole cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their in...
Each issue lists papers published during the preceding year.
Covers: channels; secretory vesicles and exocytosis; receptors/coupling mechanisms; synaptic plasticity; modulatory factors; and protein kinases and control of gene expression. Includes both abstracts of papers, and poster sessions. Illustrated.