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Biomarkers in Autoimmune Diseases of the Central Nervous System
Autoimmune diseases of the central nervous system (CNS) are a group of complex and disabling disorders characterized by the immune system mistakenly attacking the CNS. During the last 2 decades, we have witnessed a rapidly evolving spectrum of CNS autoimmune diseases, which has become a research hotspot in neurology. These include CNS inflammatory demyelinating diseases such as multiple sclerosis and neuromyelitis optical spectrum disorders, paraneoplastic, and other autoimmune encephalomyelitis and CNS involvement in systemic autoimmune diseases. Recently, although remarkable discoveries have accumulated more understanding of the autoimmune basis behind the physiopathologic mechanism, the e...
TRP-Mediated Signaling
The field of transient receptor potential (TRP) channels has gained momentum in recent years not only because of the 2021 Nobel Prize in Physiology or Medicine awarded to David Julius and Ardem Patapoutian for their discoveries of receptors for temperature and touch, but also because of the growing appreciation of the diverse and important physiological and pathophysiological functions of this diverse family of cation channels. In the past decade, there have been important discoveries in the TRP field: resolution of the 3-D structures of major subfamilies using single-particle cryogenic electron microscopy and X-ray crystallography, identification and development of selective agonists and an...
Immune Cells, Inflammation, and Cardiovascular Diseases
Inflammation, once considered a physiological response to foreign pathogens, is now recognized as a crucial pathological player in the initiation and progression of several chronic diseases, including diabetes, obesity, cancer, Alzheimer’s disease, Parkinson’s disease, and many others. Considering that cardiovascular diseases are a leading cause of death in the United States and worldwide, the identification of critical inflammatory processes is of utmost importance to devising new immune-based therapeutics that can be added to existing regimens. This book provides detailed information on aspects of inflammation and the manner in which immune activation pathways affect the progression of...
THE GREAT MASTER CHAPTER 43
THE GREAT MASTER CHAPTER 43 Using the strength of one person to deal with many powerful Demonic Daoists besieging him, Chu Xiu's strength was terrifyingly strong. Si Tu Qi's expression had completely changed. He had calculated a lot but he had not calculated that Chu Xiu's strength was now terrifying to this extent. He truly treated martial artists of the same level as nothing. After entering the True Fire Refining God realm, Chu Xiu had actually only made a move twice. Once was to discuss with Shang Tianliang, the second time was to fight Xu Yun. However, when he fought Xu Yun, only Sheng Beixian witnessed it. At that time, the people from the Demonic Dao branch had not arrived yet. This time, everyone finally got to witness So Huu's true strength, it was truly terrifying.
Heaven Official's Blessing: Tian Guan Ci Fu (Novel) Vol. 8
White No-Face's mask is off, and the final conflict has begun. Deep in the ancient caverns and lava flows of Mount Tonglu, Xie Lian must face the one whose hatred has plagued him for centuries--but this time, he won't have to do it alone. His beloved, Hua Cheng, has spent his long existence amassing the power to protect him, and now with their feelings for each other out in the open, they have all the more reason to fight for survival. In this thrilling conclusion to Heaven Official's Blessing, can Xie Lian and Hua Cheng triumph against an all-powerful foe? Also included in this final volume are five bonus tales of romance, celebration, and adventure.
Pattern Recognition
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Husband, Wait Please
she was the goddess whose divine power had been sealed.the devil tried to take her life, the knight tried to humiliate her,even a tyrant of a country squire wanted to take her!accompanying her was a young monk from samsara who had accomplished his mission.however, he was completely captivated by her.and even that supreme and supreme heavenly monarch?thus, the berserk and pitch-black demon lord was enraged. he should be her master!"humph!" this sovereign would even dare to scheme against a woman he has taken a fancy to?"all of them have been destroyed by this sovereign."wait a minute, why is there no one taking her opinion into account?all of you line up for me,the most important thing was to cultivate.pet men and the like ...we'll discuss it later!
