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The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems
This, the 148th volume of the Handbook of Experimental Pharmacology series, focuses on the very core of pharmacology, namely receptor theory. It is fitting that the originator of receptor pharmacology, A. J. CLARK, authored the fourth volume of this series 63 years ago. In that volume CLARK further developed his version of receptor theory first described four years earlier in his classic book The Mode of Action of Drugs. An examination of the topics covered in volume 4 reveals a striking similarity to the topics covered in this present volume; pharmacologists today are still as interested in unlocking the secrets of dose-response relationships to reveal the biological and che mical basis of ...
Biomimetic Materials And Design
Detailing techniques in wound healing and reconstruction, this reference describes the mechanisms and architecture of biological systems to formulate and design natural and synthetic compounds, degradable and non-degradable scaffolds, and targeted drug delivery devices. It offers strategies to control adhesive interactions, elicit specific cellular responses, and improve the biocompatibility, performance, and durability of prosthetic materials. Covering advances in the field, the book discusses the effect of topographical features on cell behaviors such as orientation, adhesion, migration, proliferation, and differentation.
Governing Medical Knowledge Commons
This book collects fifteen new case studies documenting successful knowledge and information sharing commons institutions for medical and health sciences innovation. Also available as Open Access.
Oncofertility
Oncofertility has emerged as a way to address potential lost or impaired fertility in cancer patients and survivors, with active biomedical research that is developing new ways to help these individuals preserve their ability to have biological children. In order to move beyond oncofertility as a science and medical technology and begin to address the ethical, legal, and social ramifications of this emerging field, we must give voice to scholars from the humanities and social sciences to engage in a multidisciplinary discussion. This book brings together a pool of experts from a variety of fields, including communication, economics, ethics, history, law, religion, and sociology, to examine t...
Oocyte Biology in Fertility Preservation
Fertility preservation has become one of the most important and fast growing fields of reproductive medicine. Although there are several strategies for fertility preservation in female, most of them are still considered experimental. It is important to perfect the existing technologies, but also developing new strategies should be actively sought. The future development of fertility preservation strategies should be based on the sound scientific knowledge and principles. One of the main objectives of fertility preservation in females is prevention of oocyte depletion. The mechanisms of oocyte loss and survival in the ovary are complex, which include genetic control both in germ cells and ...
Science
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The Breaking Point
For most of her life, Taylor O’Shea preferred being a loner. After her mother was incarcerated when Taylor was seven, she grew up hard—thanks in part to her construction-worker grandfather who made her tough as nails. Finally, in Chammont Point, Taylor, for the first time, finds friends who love her for her rough edges, not in spite of them. With her best friends in tow, she heads to Arizona to face the woman whose bad choices shaped the very woman Taylor has become. But the family reunion brings disappointment and even more surprises, leaving Taylor with more questions than answers. Now that Taylor’s discovered she has a half-brother, Lonnie, she sets out to find him. Helping him rebuild a life worth living becomes a mission that may save not just Lonnie but Taylor herself. Sometimes, however, helping family can push you to the breaking point.
