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Strategies in the drug discovery and development for leishmaniasis: immunomodulators, natural products, synthetic compounds, and drug repositioning
Leishmaniases are a group of tropical diseases that affect millions of people worldwide. They are considered neglected diseases prevalent in emerging countries in Latin America, West Africa, and Southeast Asia and still occurring in Mediterranean countries. There is no human vaccine available to prevent and control the disease infection. For the last 70 years, the available chemotherapy has been constituted by first-line (pentavalent antimonials) and second-line drugs (amphotericin B, pentamidine, paramomycin, and miltefosine). Its route of administration is difficult, the treatment is long, and its efficiency varies depending on the parasite species and clinical manifestations, which results in the emergence of resistant cases. Moreover, they present high toxicity to patients, and even some less toxic formulations available, are still expensive for the poorest countries’ vulnerable populations. This often leads to abandonment and failure of treatment. The medical-scientific community is facing difficulties to overcome these issues with new suitable therapies, and the identification of new drug targets. So, it means that efforts to identify new strategies must continue.
Strongly Interacting Matter in Magnetic Fields
The physics of strongly interacting matter in an external magnetic field is presently emerging as a topic of great cross-disciplinary interest for particle, nuclear, astro- and condensed matter physicists. It is known that strong magnetic fields are created in heavy ion collisions, an insight that has made it possible to study a variety of surprising and intriguing phenomena that emerge from the interplay of quantum anomalies, the topology of non-Abelian gauge fields, and the magnetic field. In particular, the non-trivial topological configurations of the gluon field induce a non-dissipative electric current in the presence of a magnetic field. These phenomena have led to an extended formula...
Nuclear Structure Physics
Nuclear structure Physics connects to some of our fundamental questions about the creation of universe and its basic constituents. At the same time, precise knowledge on the subject has lead to develop many important tools of human kind such as proton therapy, radioactive dating etc. This book contains chapters on some of the crucial and trending research topics in nuclear structure, including the nuclei lying on the extremes of spin, isospin and mass. A better theoretical understanding of these topics is important beyond the confines of the nuclear structure community. Additionally, the book will showcase the applicability and success of the different nuclear effective interaction parameter...
Advances in Parasitology
Advances in Parasitology presents the latest developments in the field of parasitology. It covers topics such as Chagas Disease Diagnostic Applications, The Role of Spatial Statistics in the Control and Elimination of Neglected Tropical Diseases in Sub-Saharan Africa, and Host–Parasite Relationships and Life Histories of Trypanosomes in Australia. Specific chapters delve into targeting parasites to suppress malaria transmission and a focus on neglected tropical diseases, such as Trypanosomiasis, Schistosomiasis and Lymphatic Filariasis. This series includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes, as well as reviews of more traditional areas, such as zoology, taxonomy and life history. - Informs and updates on all the latest developments in the field of parasitology - Includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes - Contains contributions from leading authorities and industry experts - Features reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications
The Physics and Astrophysics of Neutron Stars
This book summarizes the recent progress in the physics and astrophysics of neutron stars and, most importantly, it identifies and develops effective strategies to explore, both theoretically and observationally, the many remaining open questions in the field. Because of its significance in the solution of many fundamental questions in nuclear physics, astrophysics and gravitational physics, the study of neutron stars has seen enormous progress over the last years and has been very successful in improving our understanding in these fascinating compact objects. The book addresses a wide spectrum of readers, from students to senior researchers. Thirteen chapters written by internationally renowned experts offer a thorough overview of the various facets of this interdisciplinary science, from neutron star formation in supernovae, pulsars, equations of state super dense matter, gravitational wave emission, to alternative theories of gravity. The book was initiated by the European Cooperation in Science and Technology (COST) Action MP1304 “Exploring fundamental physics with compact stars” (NewCompStar).
Advances in Nuclear Physics
This volume comprises select peer-reviewed papers from the Indo-French Workshop on Multifragmentation, Collective Flow, and Sub-Threshold Particle Production in Heavy-Ion Reactions held at the Department of Physics, Panjab University, Chandigarh, India in February, 2019. The contents highlight latest research trends in intermediate energy nuclear physics and emphasize on the various reaction mechanisms which take place in heavy-ion collisions. The chapters contribute to the understanding of interactions that govern the dynamics at sub-nucleonic level. The book includes contributions from global experts hailing from major research facilities of nuclear physics, and provides a good balance between experimental and theoretical model based studies. Given the range of topics covered, this book can be a useful reference for students and researchers interested in the field of heavy-ion reactions.
Compact Star Physics
This introduction to compact star physics explains key concepts from general relativity, thermodynamics and nuclear physics.
Astronomy And Relativistic Astrophysics: New Phenomena And New States Of Matter In The Universe - Proceedings Of The Third Workshop (Iwara07)
This book presents scientific research on the central theme of new states of matter and new phenomena in the universe. The topics covered range from the big bang, through topics including the formation of exotic stars, black holes and the plasma of quarks and gluons by heavy ion reactions, to the influence of dark matter and dark energy in the evolution of the universe.Scientific interest in these themes has been growing: together with the development of major projects such as AUGER, LHC, FERMI Telescope, FAIR/GSI and GEO/LIGO, the diversity and scope of research on such themes has been on the rise. The content is detailed enough to capture the interest of experts in the field and is useful for future explorations on these fascinating themes.
