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Focus on Malignant Pleural Mesothelioma Immunology and Immunotherapy
Malignant pleural mesothelioma (MPM) is a rare thoracic cancer that derives from the mesothelial cells of the pleura and is causally associated with exposure to asbestos. Because of its aggressiveness and resistance to therapies, MPM prognosis is extremely poor and the 5-year survival rate is approximately 10%. Despite its poor effectiveness, chemotherapy with cisplatin and pemetrexed has long remained the standard-of-care for upfront treatment with no second line therapy available. Recently, the approval of ipilimumab (anti-CTLA-4) plus nivolumab (anti-PD-1) for the first-line treatment of unresectable MPM has marked a significant milestone, in particular for the non-epithelioid MPM subtype...
Molecular Pathology of HTLV-1
Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered, in 1980, by Gallo and co-workers. About 5-10% of HTLV-1-infected individuals are at risk of developing either a fatal malignancy, adult T-cell leukemia (ATL), or a chronic neuroinflammatory syndrome, HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Both diseases are incurable at present. Many issues concerning HTLV-1’s life cycle and pathobiology are still unsolved or controversial, and new approaches for prognostic stratification of patients and eradication of HTLV-1 infection are in high demand. In this Research Topic, the focus has been centered on discussing two main themes: the functional analysis and oncogenic potential of HTLV-1 regulatory proteins and the control of HTLV-1-associated diseases. The 22 articles in this eBook cover many different aspects of HTLV-1 infection and pathogenesis, providing new perspectives and groundwork for future studies.
Come Out from among Them, and Be Ye Separate, Saith the Lord
Believers’ Churches have their origin in the Radical Reformation of the sixteenth century. Over the past 450 years the movement has included the Brethren, Mennonites, Hutterites, various types of Baptists, and the Restoration Movement. While never a unified denominational structure, the Believers’ Churches together have been characterized by a strong personal faith in Christ, a call to discipleship and Christian activism, a high view of the authority of Scripture, and profession of faith in believers’ baptism. The Believers’ Churches have represented their beliefs in various ecumenical settings, missionary gatherings, and theological conversations. In the late 1950s, representatives ...
Building for the Future: Durable, Sustainable, Resilient
This book presents the proceedings of the fib Symposium “Building for the future: Durable, Sustainable, Resilient”, held in Istanbul, Turkey, on 5–7 June 2023. The book covers topics such as concrete and innovative materials, structural performance and design, construction methods and management, and outstanding structures. fib (The International Federation for Structural Concrete) is a not-for-profit association whose mission is to develop at an international level the study of scientific and practical matters capable of advancing the technical, economic, aesthetic, and environmental performance of concrete construction.
Big Wings
In the history of aviation there have been many attempts to produce aircraft of extraordinary proportions to expand the limits of technology and create new performance standards. With few exceptions, the early attempts did not become the successes envisaged until post-World War II when such aircraft as the Boeing B-52 long-range heavy bomber and the Boeing 747 'Jumbo Jet' airliner changed the face of aviation in both the military and civil roles. Big Wings is a well-researched, highly informative and sometimes nostalgic look at the sixteen most significant giants of the air. Each chosen aircraft is introduced and its raison d'?tre explained, then follows an in-depth review of the successful ...
Limitations of Religious Freedom
Essays presented in this volume discuss `Othering': A Necessary but Dangerous Practice; Stages of religious oppression; Apologists of Anti-Pluralism; The Campaign Against Jehovah's Witnesses About Alleged Sexual Abuse in Belgium; Discrimination and Criminalization of Jehovah's Witnesses Through Generalized State Disinformation; The Use of Anti Terrorism Laws to Repress Minority Beliefs; From the French debate on `separatism' to the renewal of anti-cultism; Regulatory Restraints on Religious Freedom in the USA; Sharing Beliefs in Nepal.
Mathematical Models and Immune Cell Biology
Whole new areas of immunological research are emerging from the analysis of experimental data, going beyond statistics and parameter estimation into what an applied mathematician would recognise as modelling of dynamical systems. Stochastic methods are increasingly important, because stochastic models are closer to the Brownian reality of the cellular and sub-cellular world.
Troy Stark Thriller Bundle: Rogue Force (#1), Rogue Command (#2), and Rogue Target (#3)
A bundle of books #1 (ROGUE FORCE), #2 (ROGUE COMMAND), and #3 (ROGUE TARGET) in Jack Mars’s Troy Stark Thriller series—a bestseller! This bundle offers books one, two, and three in one convenient file, with over 150,000 words of reading. In ROGUE FORCE, Troy finds himself partnered with an Interpol agent who is as different from him as can be, and their instant dislike is mutual. But they have an attack to stop, and only a few days to do it, and together they’ll need each other as they criss-cross Europe in a high-octane cat-and-mouse chase to shut these terrorists down. But what starts off as a straightforward mission (and an opportunity to clear his name) soon catapults Troy headfir...
