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Atlas of Liquid Biopsy
This book provides a wealth of images and extensive information on circulating tumor cells (CTCs) and other cells usually observed in blood from patients with cancer, such as giant macrophages, and circulating tumor microemboli (CTM). The field of “liquid biopsy” began with the analysis of CTCs in the early 2000s. In the beginning, molecular techniques were developed to detect these cells in the blood. However, it has since become clear that CTCs initially require a cytopathological analysis to be detected without false positive and negative results. After detection, molecular analysis can be subsequently performed. Cancer is an important cause of mortality, especially when detected in l...
Isolation and Molecular Characterization of Circulating Tumor Cells
Numerous studies have shown that elevated levels of circulating tumor cells (CTCs) in blood of cancer patients are associated with poor response to treatment and inferior survival probabilities. Despite this clinical significance, the molecular biology of CTCs remains poorly understood. The paucity in molecular information can be attributed to the tremendous technical challenges involved in isolating these extremely rare cells. Recent technological advancements in rare-cell technology, however, have allowed for the reliable enrichment and isolation of CTCs. Consequently, the use of recently developed molecular approaches —e.g., multiplexed QPCR, microarray, and next generation sequencing analyses— to profile CTCs have provided novel insights into the molecular makeup of these tumor cells. This book discusses approaches for enrichment and isolation of CTCs as well as recent advances in comprehensive molecular profiling of CTCs using cutting-edge omics technology.
Circulating Tumor Cells
The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system.
Comparative Genomics
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Atlas of Neutron Resonances
The Atlas of Neutron Resonances provides detailed information on neutron resonances, thermal neutron cross sections, and average resonance properties which are important to neutron physicist, astrophysicists, solid state physicists, reactor engineers, scientists involved in activation analysis, and evaluators of neutron cross sections. · Compilation and evaluation of the world's thermal neutron cross-sections and resonance parameters for neutron physicists, reactor engineers, and neutron evaluators.· Compilation and evaluation of coherent scattering lengths for solid state physicists and evaluators· Compilation and evaluation of average 30-keV capture cross sections for astrophysicists.· Nuclear level density parameters derived from average spacings of neutron resonances following a new approach (new feature for this edition).· Brief review of sub-threshold fission.· Comparisons of optical model predictions with neutron strength function data and scattering lengths.· Estimation of average E1 radiative widths on the basis of the generalized Landau-Fermi liquid model (a new feature for this edition).
Einstein's Greatest Mistake
Widely considered the greatest genius of all time, Albert Einstein revolutionised our understanding of the cosmos with his general theory of relativity and helped to lead us into the atomic age. Yet in the final decades of his life he was also ignored by most working scientists, his ideas opposed by even his closest friends. This stunning downfall can be traced to Einstein's earliest successes and to personal qualities that were at first his best assets. Einstein's imagination and self-confidence served him well as he sought to reveal the universe's structure, but when it came to newer revelations in the field of quantum mechanics, these same traits undermined his quest for the ultimate truth. David Bodanis traces the arc of Einstein's intellectual development across his professional and personal life, showing how Einstein's confidence in his own powers of intuition proved to be both his greatest strength and his ultimate undoing. He was a fallible genius. An intimate and enlightening biography of the celebrated physicist, Einstein's Greatest Mistake reveals how much we owe Einstein today - and how much more he might have achieved if not for his all-too-human flaws.
Minerals and Precious Stones of Brazil
"Brazil was the leading world producer of gold and of diamonds between the mid-18th century and the mid-19th century. At the present time, it is the leading world producer of iron ore, tin and niobium, and an important producer of manganese, aluminium, silicon, tantalum, rare earths, graphite, magnesite and countless other ores.....Brazil is the leading world producer of tourmaline (of all colors), of quartz (colorless, rutilated, amethyst and agate), of beryl (aquamarine, morganite and heliodore, and the second ranking world producer of emerald), of topaz (imperial, blue and colorless), alexandrite, euclase, phenakite and many others" INTRODUCTION.
Water Resources in Jordan
This is the first comprehensive, multi-disciplinary book to address water policy in Jordan. Edited by the former Minister of Water and Irrigation of Jordan, with contributions by other prominent Jordanian and international water professionals, this volume covers such areas as the population-water resources equation in Jordan; institutional and legal frameworks; the data systems used for the assessment and formulation of water policy; water allocations and uses in municipal, industrial, and agricultural sectors; social and environmental issues; and water conflict with Jordan's neighbors. The book is a must for readers interested in Middle East politics and the critical nature of water issues ...
Insulin-Like Growth Factors in Development, Cancers and Aging
This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology.
