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Diabetes and cardiovascular disease: new therapeutic interventions
Diabetes, also known as diabetes mellitus (DM), is a disease that occurs when the glucose level in the blood becomes too high (hyperglycaemia). Chronic hyperglycaemia is accompanied by both biochemical and pathological complications such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases. Diabetes mellitus can be classified into two types: type I which results from the destruction of pancreatic β-cells, leading to insulin insufficiency and type II diabetes mellitus, which is mainly related to insulin resistance. Optimal control of blood glucose levels remains the cornerstone of managing DM. To date, the major classes of antidiabetic medications used to treat diabetes include: biguanides, dipeptidyl peptidase 4 (DPP-4) inhibitors, sulfonylureas, meglitinides, thiazolidinediones (TZDs), sodium-glucose cotransporter (SGLT2) inhibitors, α-glucosidase inhibitors, glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonists and the various types of insulin. Several of these drugs may have, besides their antidiabetic properties, also important cardiovascular complications for the patients taking them.
Transcatheter Mitral and Tricuspid Valve Therapies
ranscatheter valve therapies have emerged as a viable treatments option for patients deemed high risk for conventional surgery. Whilst transcatheter aortic valve implantation (TAVI) is now established as the standard of care in high-risk aortic stenosis patients, the mitral and tricuspid frontiers have proved to be more challenging. Anatomical heterogeneity, device development, refining patient selection and until recently the absence of randomised data have all been contributing factors. For mitral regurgitation, transcatheter edge to edge repair (TEER) now benefits from positive randomised data along with significant advancements in device technology. Transcatheter mitral valve replacement (TMVR) options are also making rapid progress. More recently, tricuspid regurgitation has become the central focus of the structural heart community having previously been referred to as the “forgotten valve”
Multi-Modality Interventional Imaging, An Issue of Interventional Cardiology Clinics, E-Book
In this issue of Interventional Cardiology Clinics, guest editor Dr. Thomas Smith brings his considerable expertise to the topic of Multi-Modality Interventional Imaging. Top experts cover key topics such as 4D ICE, the next frontier in structural imaging: current technology and an IC needs assessment; tricuspid valve TEER guidance with transesophageal echocardiography and ICE; CT procedure planning for transcatheter mitral valve replacement; the use of CT for LAAO procedure planning and post-procedure assessment; and more. - Contains 10 relevant, practice-oriented topics including 4D ICE guidance of left atrial appendage closure: risks and benefits of forgoing transesophageal echocardiograp...
Magnetic Resonance Tomography
With an incredible 2400 illustrations, and written by a multitude of international experts, this book provides a comprehensive overview of both the physics and the clinical applications of MRI, including practical guidelines for imaging. The authors define the importance of MRI in the diagnosis of several disease groups in comparison or combination with other methods. Chapters dealing with basic principles of MRI, MR spectroscopy (MRS), interventional MRI and functional MRI (fMRI) illustrate the broad range of applications for MRI. Both standard and cutting-edge applications of MRI are included. Material on molecular imaging and nanotechnology give glimpses into the future of the field.
Regenerative Pharmacology
A state-of-the-art primer on the role of pharmacological sciences in regenerative medicine, for advanced students, postdoctoral fellows, and researchers.
不老不死は可能か
これまで不老不死は荒唐無稽な夢物語とみなされてきましたが、技術の進歩とともに、必ずしも実現不可能ではないと考えられるようになりました。実際、不死はともかくとして、不老は、衛生や栄養の改善、抗老化医学の進歩により、健康寿命が延びるという形で、少しずつ実現しつつあります。本書は、今後、新しい技術によって不老不死が実現できるかどうか、また不老不死の時代が来るとするなら、それに備えて今から何をすべきかを論じます。 目次 第1章 私たちはなぜ老化するのか 第2章 不老不死の三つのス...
