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Estudos Avançados em Genética e Farmacologia
Genética (do grego “genétikós”) significa “capaz de gerar”, indicando o seu papel na gênese da vida. A Genética é a ciência que estuda os genes, a hereditariedade e a transmissão de caracteres através das gerações. Durante o século XIX, essa ciência evoluiu significativamente a partir dos experimentos de Gregor Mendel com as ervilhas, que resultou na postulação das primeiras leis da Genética. O segundo grande avanço dessa ciência ocorreu durante a década de 1950, com a elucidação da estrutura do DNA. Posteriormente, houve significativos progressos na Genética que resultaram em diversas áreas de pesquisa. Atualmente, a Genética está cada vez mais incluída em ...
Mechanisms of antibiotic resistance
Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse....
Privileged Structures in Drug Discovery
A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book...
Endophytes
This book describes the various therapeutic and commercial applications of compounds produced by endophytes. Endophytes are microorganisms that reside in the living internal tissues of plants without showing any apparent symptom of their presence. During their life cycle, they establish a symbiotic or parasitic relationship with the host plant. The book discusses different kinds of compounds that these endophytes produce, and their potential properties such as antimicrobial, anti-oxidative, anti-inflammatory, anticancer, neutraceutical, immunomodulatory etc. Other prospects of entophytic biology such as fungi of wild and domesticated crop plants and their applications in sustainable agricult...
Plant and Human Health, Volume 1
Early anthropological evidence for plant use as medicine is 60,000 years old as reported from the Neanderthal grave in Iraq. The importance of plants as medicine is further supported by archeological evidence from Asia and the Middle East. Today, around 1.4 billion people in South Asia alone have no access to modern health care, and rely instead on traditional medicine to alleviate various symptoms. On a global basis, approximately 50 to 80 thousand plant species are used either natively or as pharmaceutical derivatives for life-threatening conditions that include diabetes, hypertension and cancers. As the demand for plant-based medicine rises, there is an unmet need to investigate the quali...
Phenolic Acids
This book aims at introducing the non-specialist as well as the professionals in the fields of chemistry, biochemistry, biotechnology, food science and biomedical sciences into the biochemistry, applications and health benefits of an important group of natural products, phenolic acids. The book shows how phenolic acids display a potent antioxidant capacity and therefore health promoting effects and describe the phenolic acid composition in fruits and vegetables. The book also covers industrial applications related to phenolic acids. Furthermore, the book discusses the application of phenolic acids as food additives, since the preparation of foods with a high content of phenolic acids can lead to a reduction in the use of synthetic additives, resulting in healthier foods that can be included in the functional foods group. The book is of interest to specialists in the field but also to graduate or postgraduate students that are interested in this particular group of natural products.
Plant Antioxidants and Health
This book provides a comprehensive reference guide to plant-derived antioxidants, their beneficial effects, mechanisms of action, and role in disease prevention and improving general health (anti-ageing effect). The content is divided into three main parts, the first of which covers various antioxidants (such as polyphenols, carotenoids, tocopherols, tocotrienols, glutathione, ascorbic acid), their origins, plant biochemistry and industrial utilization. In turn, the book’s second, main part focuses on antioxidants’ beneficial health effects, explains biochemical fundamentals such as the free radical theory and oxidative stress, and discusses antioxidants’ role in e.g. cancer, cardiovas...
Animals in Traditional Folk Medicine
People have relied on medicinal products derived from natural sources for millennia, and animals have long been an important part of that repertoire; nearly all cultures, from ancient times to the present, have used animals as a source of medicine. Ingredients derived from wild animals are not only widely used in traditional remedies, but are also increasingly valued as raw materials in the preparation of modern medicines. Regrettably, the unsustainable use of plants and animals in traditional medicine is recognized as a threat to wildlife conservation, as a result of which discussions concerning the links between traditional medicine and biodiversity are becoming increasingly imperative, particularly in view of the fact that folk medicine is the primary source of health care for 80% of the world’s population. This book discusses the role of animals in traditional folk medicine and its meaning for wildlife conservation. We hope to further stimulate further discussions about the use of biodiversity and its implications for wildlife conservation strategies.
