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This monograph of carefully collected articles reviews recent developments in theoretical and applied statistical science, highlights current noteworthy results and illustrates their applications; and points out possible new directions to pursue. With its enlightening account of statistical discoveries and its numerous figures and tables, Probabili
Cognitive Intelligence with Neutrosophic Statistics in Bioinformatics investigates and presents the many applications that have arisen in the last ten years using neutrosophic statistics in bioinformatics, medicine, agriculture and cognitive science. This book will be very useful to the scientific community, appealing to audiences interested in fuzzy, vague concepts from which uncertain data are collected, including academic researchers, practicing engineers and graduate students. Neutrosophic statistics is a generalization of classical statistics. In classical statistics, the data is known, formed by crisp numbers. In comparison, data in neutrosophic statistics has some indeterminacy. This ...
Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have p...
This sequel to volume 19 of Handbook on Statistics on Stochastic Processes: Modelling and Simulation is concerned mainly with the theme of reviewing and, in some cases, unifying with new ideas the different lines of research and developments in stochastic processes of applied flavour. This volume consists of 23 chapters addressing various topics in stochastic processes. These include, among others, those on manufacturing systems, random graphs, reliability, epidemic modelling, self-similar processes, empirical processes, time series models, extreme value therapy, applications of Markov chains, modelling with Monte Carlo techniques, and stochastic processes in subjects such as engineering, telecommunications, biology, astronomy and chemistry. particular with modelling, simulation techniques and numerical methods concerned with stochastic processes. The scope of the project involving this volume as well as volume 19 is already clarified in the preface of volume 19. The present volume completes the aim of the project and should serve as an aid to students, teachers, researchers and practitioners interested in applied stochastic processes.
Both an introduction and a fundamental reference, this book explores how to apply genomic, proteomic, and metabolomic technologies to surrogate tissue analysis. It reviews fundamental analytical issues and actual initial results generated using these technologies. The book covers transcriptional profiling (genomics), protein profiling (proteomics), methylation profiling (epigenomics), metabolite profiling (metabolomics) and additional biomarker identification methods that can be applied to surrogate tissues. This book is useful to researchers and scientists interested in applying novel methodologies for identifying biomarkers in the fields of pharmacology, toxicology, and medicine.
“Today, over two billion people in developing countries live without any electricity. They lead lives of misery, walking miles every day for water and firewood, just to survive. What if there was an existing, viable technology, that when developed to its highest potential could increase everyone’s standard of living, cut fossil fuel demand and the resultant pollution” said Peter Meisen, President, Global Energy Network Institute in 1997. Even though energy is available, technology was not matured enough to tap this energy in the nineties. Now, with the advancement of drilling technology, extracting heat from hot rocks has become a reality. Very soon when CO2 replaces the circulation fl...
This volume includes selected contributions presented during the 3rd edition of the international conference on WaterEnergyNEXUS, which was held in Tunisia in December 2020. This conference was organized by the University of Sfax (Tunisia), in cooperation with the Sanitary Environmental Engineering Division (SEED) of the University of Salerno (Italy), the Advanced Institute of Water Industry at Kyungpook National University (Korea) and The Energy and Resources Institute, TERI (India). The WaterEnergyNEXUS series of conferences are supported by the UNESCO World Water Association Programme (WWAP) and the International Water Association (IWA). It also enjoys the patronage of several internation...
As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Saf
Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the ...