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In this first book to provide an overview of applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets, a team of international specialists from research institutions, hospitals and companies contribute with their specific expertise. They cover a wide range of example applications for the most important diseases, such as heart and cardiovascular disorders, cancer, pharmatoxicology, infectious diseases and diseases of the nervous system. Denis Hochstrasser is an eminent scientist in the field of bioinformatics and proteomics and one of the founders of the Swiss Prot Databank as well as of the Swiss biotech company Genebio.
The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.
A variety of new cancer therapy modalities are discussed and evaluated in this book. It aims to demonstrate that the combination of classical chemo- and radiotherapy with new approaches in the field of immunotherapy can result in an improved treatment modality. Immunotherapy in this context consists of therapy with monoclonal antibodies, hematopoietic growth factors and other lymphokines. Results of early clinical trials with IL-2, GM-CSF and monoclonal antibodies against gastrointestinal tumors and melanoma are included. The progress in regional chemotherapy strategies, for example of the liver, is shown. In addition, the development of new chemotherapeutic agents with a different mode of action as well as better tolerability is presented. The use of hormones, such as LH-RH agonists, allows hormone-dependent tumors such as prostatic and breast cancer to be treated without strong adverse reactions. These recent findings give the reader insight into exciting therapeutic directions made possible by such combined, rather than single, modalities.
With contributions by numerous experts
The science of energy harvesting materials is experiencing phenomenal growth and attracting huge interest. Exploiting recently acquired insights into the fundamental mechanisms and principles of photosynthesis, it is now possible to forge entirely new and distinctive molecular materials and devise artificial photosystems and applications far remote from conventional solar cell technology. In this comprehensive treatment of energy harvesting, a team of internationally acclaimed scientists at the forefront of the subject paint a state-of-the-art picture of modern energy harvesting materials science. Covering all aspects of the subject, ranging from natural plant and bacterial photosystems, through their biologically inspired synthetic analogs, to other photoactive molecular materials such as dendrimers, the book also establishes the theory and underlying principles across the full range of light harvesting systems. With an authoritative, comprehensive and well-referenced content, it will appeal to all students, researchers and technologists interested or involved in solar energy, photobiology and photoactive materials science.
This unique synthesis of chapters from top experts in their fields targets the essential area of cancer biomarkers and the need for better and more rigorous design and clinical trials. The contributors cover several aspects of cancer molecular markers from innovation and screening to their controversies and future directions. The book is an ideal r
An up-to-date review of the morphology and pathological aspects of cell receptors, important because new therapies for various pathological conditions (genetic diseases, endocrine disorders, cancer, etc.) could be based on receptor interference.
The unexpected recent discovery and synthesis of a new form of elemental carbon has initiated an abundance of papers on all aspects of the chemistry and physics of the carbon family. Carbon Molecules and Materials takes stock of the current understanding of these various solid forms and, more particularly, of the diamond, graphite and fullerenes. After a historical background on the main properties of the element and on the latest discoveries in the field of fullerene, the chapters review the chemical and physical aspects of the allotropic forms. It describes the various properties such as thermodynamic, chemical, structural, electronic, electrical, optical and magnetic, and discusses current and potential applications. Written by scientists active in physical and chemical research on the various forms of carbon and closely related fields, the book presents a wealth of information on data and results for students and researchers interested in materials science and in the applications of advanced materials.
Fullerenes: From Synthesis to Optoelectronic Properties covers a host of topics in organic synthesis, photo- / radiation-chemistry, electron donor-acceptor interaction, supramolecular chemistry, and photovoltaics. The book reviews the state-of-the-art discoveries in these areas of "Fullerene Research" and presents selected examples to prove the potential of fullerenes as multifunctional moieties in well-ordered multicomponent composites. Fullerenes: From Synthesis to Optoelectronic Properties appeals to upper-level undergraduates, graduates, researchers, and professionals in the fields of condensed matter physicists; materials scientists; electrochemists; biochemists; solid-state, physical, organic, inorganic, and theoretical chemists; chemical, electrical, and optical engineers.